Antisecretory, gastroprotective, antioxidant and anti-Helicobcter pylori activity of zerumbone from Zingiber zerumbet (L.) Smith

PloS One
Heyam M A SidahmedJamuna Vadivelu

Abstract

Zingiber zerumbet Smith is a perennial herb, broadly distributed in many tropical areas. In Malaysia, it's locally known among the Malay people as "lempoyang" and its rhizomes, particularly, is widely used in traditional medicine for the treatment of peptic ulcer disease beyond other gastric disorders. The aim of the current study is to evaluate the gastroprotective effect of zerumbone, the main bioactive compound of Zingiber zerumbet rhizome, against ethanol-induced gastric ulcer model in rats. Rats were pre-treated with zerumbone and subsequently exposed to acute gastric ulcer induced by absolute ethanol administration. Following treatment, gastric juice acidity, ulcer index, mucus content, histological analysis (HE and PAS), immunohistochemical localization for HSP-70, prostaglandin E2 synthesis (PGE2), non-protein sulfhydryl gastric content (NP-SH), reduced glutathione level (GSH), and malondialdehyde level (MDA) were evaluated in ethanol-induced ulcer in vivo. Ferric reducing antioxidant power assay (FRAP) and anti-H. pylori activity were investigated in vitro. The results showed that the intragastric administration of zerumbone protected the gastric mucosa from the aggressive effect of ethanol-induced gastric ulcer, coinc...Continue Reading

References

Aug 1, 1978·The Journal of Pediatrics·C R King, G Prescott
Dec 1, 1990·Archives of Biochemistry and Biophysics·J M Gutteridge, B Halliwell
Jun 1, 1988·Gastroenterology·L Laine, W M Weinstein
Jan 1, 1980·Scandinavian Journal of Gastroenterology·P KirkegaardJ Christiansen
May 15, 1994·International Journal of Cancer. Journal International Du Cancer·S H GohM Yadav
Jul 21, 1998·Annals of the New York Academy of Sciences·A Mathew, R I Morimoto
Dec 22, 1998·The American Journal of Gastroenterology·J W KonturekW Domschke
Aug 31, 1999·British Journal of Cancer·M I SaundersA Rojas
Sep 10, 2002·Toxicology and Applied Pharmacology·Jin Sheng GuoMarcel Wing Leung Koo
Jun 14, 2003·Fundamental & Clinical Pharmacology·Brendan J R Whittle
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Susumu Okabe, Kikuko Amagase
Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Aug 24, 2006·Helicobacter·Masanori Hatakeyama, Tomasz Brzozowski
Dec 8, 2006·Bioorganic & Medicinal Chemistry·Kishor S JainAshok V Bhosale
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James H Jorgensen, Janet F Hindler
Oct 5, 2007·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Fernando Canani KlopellSérgio Faloni de Andrade
Oct 16, 2007·BioTechniques·Tony J Collins
Nov 28, 2007·Annual Review of Pathology·John C Atherton
Apr 26, 2008·Journal of Clinical Biochemistry and Nutrition·Makoto Sasaki, Takashi Joh
Jun 14, 2008·Gastroenterology·Loren LaineAndrzej Tarnawski
Sep 2, 2008·Journal of Ethnopharmacology·Thiago de Mello MoraesClélia Akiko Hiruma-Lima
Dec 17, 2008·Journal of Ethnopharmacology·Renata de Camargo GomesClélia Akiko Hiruma-Lima
Apr 4, 2009·Journal of Biomedicine & Biotechnology·Siddig Ibrahim Abdel WahabSyam Mohan
Apr 29, 2009·Journal of Ethnopharmacology·V J ShineS Rajasekharan
Jul 25, 2009·Antioxidants & Redox Signaling·Rao Muralikrishna Adibhatla, James Franklin Hatcher
Aug 18, 2009·Lancet·Peter MalfertheinerKenneth E L McColl
Oct 1, 2009·Chemico-biological Interactions·Jong-Il ChoiJu-Woon Lee
Nov 17, 2009·Journal of Biomedicine & Biotechnology·A D van der MeerI Vermes
Mar 17, 2010·Best Practice & Research. Clinical Gastroenterology·Zsolt Tulassay, László Herszényi

❮ Previous
Next ❯

Citations

Oct 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katayoon KalantariRosfarizan Mohamad
Jul 18, 2017·Food & Function·Md Areeful HaqueSyed Nasir Abbas Bukhari
Feb 6, 2019·Journal of Clinical Medicine·Lucija KunaMartina Smolic
Sep 29, 2018·Food Science and Biotechnology·Ai Mun CheongKar Lin Nyam
Jun 4, 2019·Canadian Journal of Microbiology·Da-Seul Shin, Yong-Bin Eom
Jan 21, 2017·BMC Veterinary Research·Nahla Saeed Al-WajeehMahmood Ameen Abdulla
Sep 22, 2019·International Journal of Molecular Sciences·Soonjae HwangKi-Jong Rhee
Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John F Lechner, Gary D Stoner
Dec 28, 2019·Journal of Family Medicine and Primary Care·Hassan Kiani AhmadabadiFarhad Jafari
Nov 15, 2018·BMC Complementary and Alternative Medicine·Thiago Moreira da SilvaGemilson Soares Pontes
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyun Jun WooSa-Hyun Kim
Dec 20, 2017··Asyafra NabilaErindyah Retno Wikantyasning

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
biopsy
light microscopy

Software Mentioned

SPSS
GraphPad
Graph Pad Prism
image J
GraphPad Prism

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.