Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats

Epilepsy Research
H UysalI H Ayhan

Abstract

The present study was undertaken to evaluate the antiseizure activity spectrum of insulin against various behavioral seizure models in rats. Insulin was injected intraperitoneally (i.p.) at a test dose of 1 U/kg. Dextrose (3 g/kg) was administered simultaneously with insulin to counteract its hypoglycemic effect and induce a normoglycemic state. Insulin was found to significantly decrease the incidence, intensity and mortality rate and prolong the latency of generalized tonic-clonic convulsions induced by pentylenetetrazole (60 mg/kg i.p.) and significantly decrease the intensity and mortality rate and prolong the latency of generalized tonic-clonic convulsions induced by penicillin (2000 U/intracerebrocortical). Insulin was not only found to prolong the latency of all the seizure components but was found to reduce the incidence of focal myoclonic twitches and generalized tonic-clonic convulsions induced by kainic acid (12 mg/kg i.p.) as well. Insulin was shown to be ineffective to suppress ouabain (5 micrograms/intracerebroventricular) induced seizures. These findings indicate that insulin possesses a broad spectrum of antiseizure activity in rats. Interaction with brain Na(+)-K(+)-ATPase has been discussed as a possible mecha...Continue Reading

References

Oct 1, 1975·The Journal of Physiology·W A GavryckR C Thompson
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Jan 1, 1989·The International Journal of Neuroscience·A S Abdul-GhaniA Saca'an
Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
Sep 1, 1988·Neurochemical Research·R P Kwok, A V Juorio
Apr 1, 1988·Neurochemical Research·M K RaizadaD LeRoith
Aug 1, 1973·Canadian Journal of Physiology and Pharmacology·K IzumiA Barbeau
Mar 30, 1984·Biochemical and Biophysical Research Communications·D E RhoadsE Raghupathy
Apr 15, 1981·Experientia·H G BernsteinM Ziegler
Mar 21, 1983·Biochimica Et Biophysica Acta·R D Moore
Aug 20, 1984·Brain Research·R A PalovcikM K Raizada
Jan 1, 1994·Progress in Neurobiology·G Sperk

❮ Previous
Next ❯

Citations

Aug 4, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Meril BakaMehmet Turgut
Dec 31, 2002·European Journal of Pharmacology·Gyöngyi HorvathJose Manuel Baeyens
Dec 10, 1999·Epilepsy Research·P A Schwartzkroin
Mar 1, 2002·Environmental Toxicology and Pharmacology·Suzan E UsanmazNevin Vural
Feb 20, 2008·BMC Evolutionary Biology·Mike AdamS Steven Potter
Mar 9, 2005·Journal of Zhejiang University. Science. B·Ying-Jun LuXiao-Xiang Zheng
Aug 23, 2011·Epilepsy Research·Liu Lin Thio
Jun 23, 2000·Life Sciences·C R HungC S Shih

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.