Antiseizure medication withdrawal in seizure-free patients with PCDH19-related epilepsy: A multinational cohort survey.

Seizure : the Journal of the British Epilepsy Association
Ángel Aledo-SerranoAntonio Gil-Nagel

Abstract

PCDH19-related epilepsy is usually refractory to current antiseizure medications (ASM), but seizures are easier to control especially after the second decade of life. Nonetheless, there is no evidence regarding the withdrawal of ASM in this clinical scenario. We aimed to evaluate the outcomes of attempts to discontinue ASM in seizure-free patients with PCDH19-related epilepsy. This survey was a cross-sectional study of patients with PCDH19-related epilepsy open between June 2019 and February 2020 and implemented in collaboration with international patient advocacy groups. Caregivers or patients were asked to fill out an anonymous questionnaire of clinical data about the attempts of ASM reduction. The survey received 42 unique responses with collected data of 77 attempts of ASM withdrawal. Median age at the ASM reduction was 10 years and mean duration of the previous seizure-free period was 35.8 months. Overall, 88.3 % had seizure recurrence (p < 0.001). After seizure recurrence, the medication had to be increased above the previous ASM dose in 36.5 % and come back to the previous one in 25.4 % cases. 5.2 % did not become seizure-free again. Only 2.6 % cases had their ASM totally withdrawn. Patients without seizure recurrence we...Continue Reading

References

Apr 8, 2015·Epilepsy & Behavior : E&B·Marco MulaTim J von Oertzen
Jan 29, 2016·Seizure : the Journal of the British Epilepsy Association·Jan LotteGerhard Kluger
May 14, 2017·Lancet Neurology·Jacqueline A French
Oct 7, 2017·Developmental Medicine and Child Neurology·Lieven LagaeAlysia Battersby
Jan 30, 2018·Epilepsia·Lacey SmithAnnapurna Poduri
Jan 14, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Lynette G SadleirIngrid E Scheffer

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