PMID: 8584755Oct 20, 1995Paper

Antisense inhibition of neuropeptide Y (NPY)-Y1 receptor expression blocks the anxiolytic-like action of NPY in amygdala and paradoxically increases feeding

Regulatory Peptides
M Heilig

Abstract

Two prominent actions of centrally administered neuropeptide Y (NPY) are to reduce experimental anxiety and to increase food intake. Agonist administration studies suggest the former effect to be mediated by NPY-Y1 receptors in the amygdala, while the receptor specificity of the latter action is not entirely understood. Antisense inhibition of Y1 receptor expression has confirmed an anxiolytic action of endogenous NPY, but has not been used to examine its anatomical mediation, or to address whether Y1 receptors are involved in the feeding effects of NPY. In the present study, rats were antisense-treated in a manner previously demonstrated to reduce Y1 receptor density. When preceded by intraventricular administration of an inactive oligonucleotide, bilateral NPY administration in the amygdala was anxiolytic in the elevated plus-maze model. Intraventricular antisense administration, on the other hand, blocked this action of NPY, providing further support for mediation of NPY-induced anxiolysis by Y1 receptors in amygdala. Cumulative food intake was paradoxically increased by antisense treatment, suggesting that NPY-induced feeding may not be mediated by Y1 receptors. Locomotor activity or habituation to novelty were not affected...Continue Reading

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Citations

Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Sachin MoonatSubhash C Pandey
Apr 7, 2011·Journal of Cardiovascular Translational Research·Lijun LiZofia Zukowska
Nov 6, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Antonio P SilvaEric Grouzmann
Sep 6, 2002·Physiology & Behavior·Cheryl C MillerGaylen L Edwards
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·Tammy J SajdykDonald R Gehlert
Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·C L EhlersT K Li
May 30, 2002·Neuroscience and Biobehavioral Reviews·Ants KaskRémi Quirion
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·J Menard, D Treit
Apr 24, 2001·Pharmacology & Therapeutics·J C ClaphamM Tadayyon
May 10, 2003·Brain Research. Brain Research Reviews·Dirk Van OekelenJosée E Leysen
Nov 5, 1998·Regulatory Peptides·A O SchaffhauserA Stricker-Krongrad
Jan 23, 1998·Peptides·H KlemfussK T Britton
Mar 11, 1998·Peptides·M NakajimaM Kasuga
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Jan 30, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrei I MoloshAnantha Shekhar
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·J R Walker, G F Koob
Nov 24, 1998·Antisense & Nucleic Acid Drug Development·H A WielandB Krist
Jul 2, 2009·Psychiatry and Clinical Neurosciences·Yuko OkahisaShigetoshi Kuroda
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Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alisa R GutmanMichael Davis

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