Antisense lncRNA FOXF1-AS1 Promotes Migration and Invasion of Osteosarcoma Cells Through the FOXF1/MMP-2/-9 Pathway

International Journal of Biological Sciences
Zhu Kun-PengMa Xiao-Long

Abstract

Osteosarcoma (OS) is the most common primary malignant bone cancer in children and adolescents. Long non-coding RNAs (lncRNAs) have been shown to play significant role in various cancers, including OS. In a previous study, we have reported that a novel antisense lncRNA FOXF1-AS1, also known as FENDRR, could sensitize doxorubicin-resistance of OS cells through down-regulating ABCB1 and ABCC1. Here in, the critical role of FOXF1-AS1 in regulating OS progression was further investigated. Firstly, we found that FOXF1-AS1 and its antisense transcript FOXF1 expression were positively up-regulated in OS tissues and cell lines and correlated with poor prognosis of OS patients. Besides, FOXF1-AS1 as well as FOXF1 silencing significantly inhibited cell proliferation, migration, invasion of OS cells and tumor growth both in vitro and vivo through decreasing the expression of MMP2 and MMP9, whereas enhanced expression of FOXF1-AS1 had the opposite effects. In addition, mechanistically, both of FOXF1-AS1 and FOXF1 could regulate the expression of MMP2 and MMP9 at mRNA and protein levels, whereas FOXF1-AS1 could influence the FOXF1expression but FOXF1 did not have the same effect on FOXF1-AS1. Rescue assay further showed that FOXF1-AS1 overe...Continue Reading

Citations

May 7, 2020·Cancer Metastasis Reviews·Yannasittha Jiramongkol, Eric W-F Lam
Feb 6, 2020·British Journal of Cancer·Amelia Acha-SagredoTriantafillos Liloglou
Nov 13, 2020·European Journal of Ophthalmology·Qinying Huang, Jinying Li
Mar 27, 2021·Cancer Letters·Saeed AshrafizavehKwang Seok Ahn
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qingyuan ZhengWenzhi Guo
Jun 22, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zenghui GuZhaoming Ye
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Aug 28, 2021·International Journal of Molecular Sciences·Lakmini Kumari SenavirathnaLin Liu
Aug 21, 2021·Current Pharmaceutical Design·Wen XuChengfu Yuan

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Methods Mentioned

BETA
antisense oligonucleotide
transfection

Software Mentioned

Graph pad Prism
SPSS

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