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Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders

Brain : a Journal of Neurology

Nov 18, 2019

Ana Catarina SilvaLuís Pereira de Almeida

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Abstract

Polyglutamine (polyQ) disorders are a group of nine neurodegenerative diseases that share a common genetic cause, which is an expansion of CAG repeats in the coding region of the causative genes that are otherwise unrelated. The trinucleotide expansion encodes for an expanded polyQ trac...read more

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Antistreptolysin O
Cell Growth
Clinical Trials
DNA, Single-Stranded
Genes
Huntington Disease
Nerve Degeneration
Nucleic Acids
RNA Splicing
Chorionic alpha(2)-microglobulin
17
1
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Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders

Brain : a Journal of Neurology

Nov 18, 2019

Ana Catarina SilvaLuís Pereira de Almeida

PMID: 31738395

DOI: 10.1093/brain/awz328

Abstract

Polyglutamine (polyQ) disorders are a group of nine neurodegenerative diseases that share a common genetic cause, which is an expansion of CAG repeats in the coding region of the causative genes that are otherwise unrelated. The trinucleotide expansion encodes for an expanded polyQ trac...read more

Mentioned in this Paper

Antistreptolysin O
Cell Growth
Clinical Trials
DNA, Single-Stranded
Genes
17
1

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Paper Details
References
  • References166
  • Citations
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  • References166
  • Citations
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