Antisense phosphorothioates as antivirals against human immunodeficiency virus (HIV) and hepatitis B virus (HBV)

Toxicology Letters
M MatsukuraG Zon

Abstract

For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activities of phosphorothioate oligodeoxynucleotides (S-oligo) were classified into sequence non-specific (non-antisense) and sequence specific (antisense). We found that toxicity of S-oligo could be also classified into the same 2 categories. Since some of non-specific toxicity is dependent on experimental conditions, in each experiment, we should pay attention to minimize non-specific toxicity of the oligomers.

Citations

Dec 15, 2015·Journal of Hepatology·Gaetan BillioudStefan Wieland
Mar 4, 2015·Advanced Drug Delivery Reviews·Yuhua WangLeaf Huang
Jul 7, 2007·Archives of Medical Research·Margarita PardoVicente Carreño
Mar 3, 2015·World Journal of Hepatology·Maren GebbingAnja Ehrhardt

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