Antisense RNA-regulated programmed cell death

Annual Review of Genetics
K GerdesN D Mikkelsen

Abstract

Eubacterial plasmids and chromosomes encode multiple killer genes belonging to the hok gene family. The plasmid-encoded killer genes mediate plasmid stabilization by killing plasmid-free cells. This review describes the genetics, molecular biology, and evolution of the hok gene family. The complicated antisense RNA-regulated control-loop that regulates posttranscriptional and postsegregational activation of killer mRNA translation in plasmid-free cells is described in detail. Nucleotide covariations in the mRNAs reveal metastable stem-loop structures that are formed at the mRNA 5' ends in the nascent transcripts. The metastable structures prevent translation and antisense RNA binding during transcription. Coupled nucleotide covariations provide evidence for a phylogenetically conserved mRNA folding pathway that involves sequential dynamic RNA rearrangements. Our analyses have elucidated an intricate mechanism by which translation of an antisense RNA-regulated mRNA can be conditionally activated. The complex phylogenetic relationships of the plasmid- and chromosome-encoded systems are also presented and discussed.

References

Sep 1, 1992·Microbiological Reviews·R Young
Jan 1, 1992·Annual Review of Biochemistry·S Hiraga
Mar 1, 1992·Molecular Microbiology·N Ogasawara, H Yoshikawa
Jan 1, 1991·Annual Review of Biochemistry·Y EguchiJ Tomizawa
Jul 1, 1991·Molecular Microbiology·L K PoulsenP Andersson
Jul 1, 1991·Molecular Microbiology·L K PoulsenP Andersson
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M H de Smit, J van Duin
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J GoldsteinM Inouye
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W P Donovan, S R Kushner
Jan 1, 1989·Annual Review of Genetics·K Nordström, S J Austin
Apr 1, 1988·Journal of Bacteriology·S TsuchimotoE Ohtsubo
Apr 1, 1988·Molecular & General Genetics : MGG·H NakamuraY Anraku
Jan 1, 1985·Journal of Bacteriology·K GerdesS Molin
Jan 1, 1988·Annual Review of Biochemistry·L Gold
Aug 1, 1987·Molecular & General Genetics : MGG·P B RasmussenS Molin
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K GerdesS Molin
Aug 23, 1972·Nature: New Biology·Y Onishi, D Schlessinger
Jul 14, 1971·Nature: New Biology·M SoginC R Woese
Nov 1, 1980·Journal of Bacteriology·Y Ohnishi, S Akimoto
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T Ogura, S Hiraga
Nov 25, 1981·Nucleic Acids Research·H F NollerC R Waese
Jul 1, 1995·Molecular Microbiology·R B Jensen, K Gerdes

❮ Previous
Next ❯

Citations

Oct 1, 2003·Journal of Biosciences·Soundarapandian VelmuruganMakkuni Jayaram
Mar 24, 2004·Trends in Microbiology·Hanna Engelberg-KulkaRonen Hazan
May 22, 2002·Biochimica Et Biophysica Acta·Sabine Brantl
Nov 30, 2002·Biochimie·Jord H A Nagel, Cornelis W A Pleij
Jul 6, 2000·Trends in Microbiology·J Møller-JensenK Gerdes
Dec 30, 1998·Trends in Biochemical Sciences·E G Wagner, S Brantl
Apr 4, 2000·Current Opinion in Microbiology·T Franch, K Gerdes
May 7, 2003·Current Opinion in Microbiology·Eric MasséSusan Gottesman
Sep 3, 2005·Nature Reviews. Microbiology·Søren J SørensenStefan Wuertz
Oct 10, 1998·Molecular Microbiology·M Gotfredsen, K Gerdes
Jun 11, 1999·Molecular Microbiology·K Pedersen, K Gerdes
Nov 6, 2004·Nucleic Acids Research·Christian HoischenStephan Diekmann
Feb 19, 2005·Nucleic Acids Research·Mitsuoki KawanoGisela Storz
Dec 21, 2006·Nucleic Acids Research·A XayaphoummineH Isambert
Jul 21, 2006·Nucleic Acids Research·J H A NagelC W A Pleij
Jan 2, 2010·Nucleic Acids Research·Ivan DotuPeter Clote
Nov 20, 2012·Nucleic Acids Research·Erik Johnson, Ranjan Srivastava
Aug 24, 2013·Nucleic Acids Research·Natalie Jahn, Sabine Brantl
Jun 28, 2002·Nucleic Acids Research·J H A NagelC W A Pleij
Aug 20, 2005·Journal of Bacteriology·Urszula Zielenkiewicz, Piotr Ceglowski
Sep 17, 2005·Journal of Bacteriology·Jessica M SilvaggiRichard Losick
Dec 4, 2012·Microbiology and Molecular Biology Reviews : MMBR·Wai Ting ChanManuel Espinosa
Jun 15, 2005·Annual Review of Biochemistry·Gisela StorzKaren M Wassarman
Jun 8, 2006·Annual Review of Biochemistry·Santanu Kumar GhoshMakkuni Jayaram
Aug 19, 2007·Microbial Cell Factories·Louise Carøe Vohlander RasmussenKim Kusk Mortensen
Aug 7, 2007·Genome Biology·Emeric W Sevin, Frédérique Barloy-Hubler
Aug 24, 2007·PLoS Biology·Erel LevineTerence Hwa

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
restriction modification
Infection

Software Mentioned

fbi
tac

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis