PMID: 8971471Nov 1, 1996Paper

Antisense therapy

Current Opinion in Oncology
R Narayanan, S Akhtar

Abstract

The sequence specificity of the antisense technique makes it an attractive basis for novel molecular therapeutics. Inhibition of gene expression by antisense in cell culture models has provided a strong rationale for identification and validation of disease targets. Analogues modified from normal phosphodiester oligodeoxynucleotides have entered clinical trials of diseases including AIDS, cancer, and inflammation. It is becoming increasingly apparent that these drugs act by means of a complex mechanism of action, and some of their effects can be sequence independent. Nevertheless, these oligodeoxynucleotides offer considerable promise as novel molecular drugs. Harnessing the therapeutic potential of this powerful technique depends on elucidation of the complex mechanism of action so that effective and meaningful therapeutic modalities can be realized.

Citations

Aug 22, 2001·Lancet·I TammG Hartmann
Jun 6, 2000·Advanced Drug Delivery Reviews·M B BallyD L Reimer
Jan 6, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M BertonR Gurny
Jan 15, 1997·Journal of the National Cancer Institute·R Narayanan
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·D L SokolA M Gewirtz
Apr 16, 2005·World Journal of Gastroenterology : WJG·Han-Ping WuYuan Tian
Jun 17, 1998·International Journal of Cancer. Journal International Du Cancer·S HasegawaK Miyazaki
Apr 18, 1998·Methods : a Companion to Methods in Enzymology·P M Epstein

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