Antiseptic Agents Elicit Short-Term, Personalized, and Body Site-Specific Shifts in Resident Skin Bacterial Communities

The Journal of Investigative Dermatology
Adam J SanMiguelElizabeth A Grice

Abstract

Despite critical functions in cutaneous health and disease, it is unclear how resident skin microbial communities are altered by topical antimicrobial interventions commonly used in personal and clinical settings. Here we show that acute exposure to antiseptic treatments elicits rapid but short-term depletion of microbial community diversity and membership. Thirteen subjects were enrolled in a longitudinal treatment study to analyze the effects of topical treatments (i.e., ethanol, povidone-iodine, chlorhexidine, and water) on the skin microbiome at two skin sites of disparate microenvironment: forearm and back. Treatment effects were highly dependent on personalized and body site-specific colonization signatures, which concealed community dynamics at the population level when not accounted for in this analysis. The magnitude of disruption was influenced by the identity and abundance of particular bacterial inhabitants. Lowly abundant members of the skin microbiota were more likely to be displaced, and subsequently replaced, by the most abundant taxa prior to treatment. Members of the skin commensal family Propionibactericeae were particularly resilient to treatment, suggesting a distinct competitive advantage in the face of di...Continue Reading

Citations

Feb 14, 2019·JAMA Dermatology·Tiffany C Scharschmidt
Jul 30, 2019·The British Journal of Dermatology·C Bernigaud, O Chosidow
Aug 25, 2019·American Journal of Clinical Dermatology·Anna PothmannPeter Elsner
Feb 15, 2020·International Journal of Molecular Sciences·Ewan A LanganDetlef Zillikens
Jun 11, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick G HoganStephanie A Fritz
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ahmed BabikerMary K Hayden
Dec 22, 2020·Plastic and Reconstructive Surgery·Greg G HillebrandRong Kong
Aug 8, 2020·The British Journal of Dermatology·M B LousadaR Paus
May 16, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Amanda W ErnlundDavid K Karig
Dec 2, 2020·American Journal of Infection Control·Timothy L Wiemken, Aaron C Ericsson
Sep 14, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rachel BaurStacey E Anderson
Sep 14, 2021·Acta Dermato-venereologica·Michael BrandweinShiri Meshner

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