PMID: 6403097Mar 1, 1983Paper

Antiseptics in the treatment of bacterial peritonitis in rats

The British Journal of Surgery
D J McAvincheyG Lynch

Abstract

A controlled mixed peritoneal infection was produced by inoculation of bacteria into the peritoneum and peritonitis was allowed to become established. A laparotomy was performed and peritoneal toilet with a variety of agents was carried out. Local povidone-iodine in the inflamed peritoneum proved to be not only of no benefit but, in fact, to be toxic. In the standard concentrations recommended it proved lethal. Noxythiolin 2.5 per cent also had no beneficial effect. There was a significant difference between the effect of povidone-iodine when instilled into an inflamed peritoneum and instillation into the intact peritoneal cavity. We would advise caution in the use of these antiseptics in any situation in which local defence mechanisms have been compromised as a result of established infection.

References

Oct 1, 1979·Current Problems in Surgery·T HauR L Simmons
Jan 1, 1978·The British Journal of Surgery·D J Stewart, N A Matheson
Jun 1, 1978·Annals of Surgery·M C LagardeI Cohn
May 1, 1975·Annals of Surgery·H H StoneC E Geheber
Sep 1, 1975·The Journal of Infectious Diseases·W M WeinsteinS L Gorbach
Aug 1, 1975·The British Journal of Surgery·D W KingB N Brooke
Dec 1, 1975·The Surgical Clinics of North America·B Lorber, R M Swenson
Apr 1, 1974·The Journal of Surgical Research·J E LavigneB F Rush
Jul 1, 1970·The British Journal of Surgery·M K Browne, J L Stoller
Mar 1, 1981·The British Journal of Surgery·J A WalshJ J Finlay-Jones
Apr 26, 1980·British Medical Journal
Jul 1, 1962·The British Journal of Surgery·H ELLIS

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Citations

Jan 1, 1988·Veterinary Research Communications·J NdikuweraE Z Mushi
Jul 1, 1985·Diseases of the Colon and Rectum·H C Kuijpers
Sep 1, 1984·The British Journal of Surgery·D J McAvincheyG Lynch
Nov 1, 1984·The British Journal of Surgery

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