Antisera recognising HLA-A, -B and DRW antigens raised in rhesus monkeys

Tissue Antigens
C J BarnstableW F Bodmer

Abstract

Rhesus monkeys were immunized with partially purified HLA-A, -B, -C and DR antigens. The resulting sera were shown to have activity against species-specific determinants on both HLA-A, -B, -C chains and beta 2 microglobulin by the use of somatic cell hybrids. When this was removed by absorption, the sera showed activity against three of the four HLA-A and -B antigens in the immunogen when tested on a panel of peripheral blood lymphocytes and T cells. Antibodies recognizing HLA-DR antigens were detected by testing platelet absorbed sera on a panel of typed lymphoblastoid cell lines. After absorption to remove activity against species-specific determinants on the HLA-DR antigens, two cross reacting specificities were defined. One consisted of a determinant in common between HLA-DRw1, 2 and 6 and the other a putative determinant in common between HLA-DRw4, and 5. The nature and significance of these cross-reacting groups of HLA-DR antigens is discussed in the light of current HLA-DR serology and the nature of HLA antigens in general.

References

Mar 1, 1977·Tissue Antigens·D AlbrechtsenE Thorsby
Jan 1, 1977·Scandinavian Journal of Immunology·D SnaryM J Crumpton
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·C J BarnstableM J Crumpton
Jan 1, 1978·Scandinavian Journal of Immunology·B G SolheimE Thorsby
May 1, 1979·Tissue Antigens·C J BarnstableW F Bodmer
Jan 1, 1979·Immunological Reviews·F M BrodskyW F Bodmer
Aug 1, 1977·European Journal of Immunology·D SnaryM J Crumpton
Feb 1, 1976·Tissue Antigens·P GoodfellowD Snary
Feb 1, 1976·European Journal of Immunology·P Cresswell, J L Ayres
Dec 1, 1976·Transplantation·P N GoodfellowM J Crumpton
Sep 1, 1976·The Journal of Experimental Medicine·D B MurphyH O McDevitt
Jan 1, 1975·International Archives of Allergy and Applied Immunology·A B WilsonR R Coombs

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