PMID: 8583292Nov 1, 1995Paper

Antiserum to tumor necrosis factor and failure to prevent murine colitis

Journal of Pediatric Gastroenterology and Nutrition
A D OlsonD G Remick

Abstract

Cytokines regulate many aspects of disease and have been implicated as mediators of the inflammatory reactions in patients with both ulcerative (UC) and Crohn's colitis. We examined the local and systemic appearance of tumor necrosis factor (TNF) and interleukin 6 (IL-6) in an experimental animal model of inflammatory bowel disease. Colitis was induced in CBA/J mice by adding dextran sulfate sodium (DSS), 5% (wt/vol), to their water. DSS-induced colitis is a reproducible animal model for evaluating the role of cytokines in the pathology of colitis. Animals were weighed daily, and stools were checked for the presence of blood. Groups of mice were killed daily, blood samples were taken for measurement of plasma cytokine levels, and colonic samples were taken for histology and measurement of TNF and IL-6 bioactivity. Mice fed DSS developed colitis with bloody diarrhea, weight loss, and colonic inflammation by days 5-9. Histologic examination of the colons showed focal crypt destruction and ulceration. In mice with DSS-induced colitis no TNF was detectable in colonic tissue extracts or in plasma. In contrast, plasma IL-6 was detectable from days 4 to 9 and was detectable in colonic tissue in only a few (two of four) terminally ill ...Continue Reading

Citations

May 30, 2009·Inflammatory Bowel Diseases·RoseMarie Stillie, Andrew W Stadnyk
Jan 1, 1997·Peptides·N RajoraJ M Lipton
Nov 3, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sandra M OcampoJose C Perales
Aug 8, 2002·Journal of Gastroenterology and Hepatology·Tadao BambaYoshihide Fujiyama
Apr 19, 2003·Journal of Gastroenterology and Hepatology·Yuji NaitoToshikazu Yoshikawa
May 19, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lesley RheeDavid L Boone
Mar 12, 2008·Journal of Inflammation·Laura P Hale, George Cianciolo
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marco MariniFabio Cominelli
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