Sep 14, 1999

Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects

Planta medica
A MeisterA Buschauer

Abstract

The effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl2, carbachol, histamine, prostaglandin F2 alpha). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F2 alpha being most efficiently antagonized.

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Mentioned in this Paper

Histamine Measurement
Ethanol
Prostaglandin F2 Alpha Measurement
Ethanol Measurement
Cavia
Contraction (Finding)
Trachea
Smooth Muscle
Cell Differentiation Process
Antispasmodics

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