Antisynthetase syndrome presenting as interstitial lung disease: a case report

Journal of Medical Case Reports
Aliena BadshahMohammad Humayun

Abstract

Antisynthetase syndrome is a relatively uncommon entity, and can be easily missed if not specifically looked for in adults whose initial presentation is with interstitial lung disease. Its presentation with interstitial lung disease alters its prognosis. This case report describes a 27-year-old Pakistani, Asian man, a medical student, with no previous comorbidities or significant family history who presented with a 3 months' history of low grade fever and lower respiratory tract infections, associated with exertional dyspnea, arthralgias, and gradual weight loss. During these 3 months, he had received multiple orally administered antibiotics for suspected community-acquired pneumonia. When he presented to us, he was pale and febrile. A chest examination was significant for bi-basal end-inspiratory crackles. Preliminary investigations revealed raised erythrocyte sedimentation rate. High resolution computed tomography of his chest showed fine ground-glass attenuation in posterior basal segments of both lower lobes suggestive of interstitial lung disease. He was started on dexamethasone, to which he responded and showed improvement. However, during the course of events, he developed progressive proximal muscle weakness. Further in...Continue Reading

References

Sep 4, 2007·Seminars in Respiratory and Critical Care Medicine·Maryam FathiGöran Tornling
Mar 11, 2011·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Joshua SolomonKevin K Brown
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Jun 7, 2017·JAMA Neurology·Eri NoguchiIchizo Nishino

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BETA
X-ray
biopsy

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GeneXpert

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