Antitags: SERS-encoded nanoparticle assemblies that enable single-spot multiplex protein detection

Advanced Materials
Nekane Guarrotxena, Guillermo C Bazan

Abstract

Simultaneous detection of multiple proteins on a single spot can be efficiently achieved by using multiplexed surface-enhanced Raman spectroscopy (SERS)-encoded nanoparticle 'antitags' consisting of poly(ethylene glycol) (PEG)-protected silver dimers (and higher aggregates) and antibody-tagging entities. The effective SERS-based multivariate deconvolution approach guarantees an accurate and successful distinguishable identification of single and multiple proteins in complex samples. Their potential application in multiplexed SERS bioimaging technology can be easily envisaged.

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Feb 3, 2016·ACS Nano·Judit Morla-FolchLuca Guerrini
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Dec 19, 2017·ACS Applied Materials & Interfaces·Bing LiuXiangwei Zhao

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