Antithrombin administration during experimental cardiopulmonary resuscitation

Resuscitation
Jakob JohanssonSten Rubertsson

Abstract

To determine whether antithrombin (AT) administration during cardiopulmonary resuscitation (CPR) increased cerebral circulation and reduced reperfusion injury. Ventricular fibrillation was induced in 24 anaesthetised pigs. After a 5-min non-intervention interval, CPR was started. The animals were randomised into two groups. The treatment group received AT (250 U/kg) and the control group received placebo, after 7 min of CPR. Defibrillation was attempted after 9 min of CPR. If restoration of spontaneous circulation (ROSC) was achieved, the animals were observed for 4 h. Cortical cerebral blood flow was measured using laser-Doppler flowmetry. Cerebral oxygen extraction was calculated to reflect the relation between global cerebral circulation and oxygen demand. Measurements of eicosanoids (8-iso-PGF(2alpha) and 15-keto-dihydro-PGF(2alpha)), AT, thrombin-antithrombin complex (TAT) and soluble fibrin in jugular bulb plasma were performed to detect any signs of cerebral oxidative injury, inflammation and coagulation. There was no difference between the groups in cortical cerebral blood flow, cerebral oxygen extraction, or levels of eicosanoids, TAT or soluble fibrin in jugular bulb plasma after ROSC. In the control group reduction o...Continue Reading

References

Mar 27, 1998·Seminars in Thrombosis and Hemostasis·G Dickneite
Sep 28, 2000·Critical Care Medicine·F FourrierA Tournoys

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Citations

Nov 23, 2006·Critical Care Medicine·Jose A Adams
Apr 24, 2008·Critical Care Medicine·Karl B KernMichael Loedl
Feb 8, 2016·The American Journal of Emergency Medicine·Qin YinChunsheng Li
Oct 17, 2017·Frontiers in Medicine·Takeshi Wada

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