Abstract
Antithrombin (AT) drop during cardiac surgery has been described. The causes and the effects of this phenomenon are not clear. The objective of the study is to evaluate the relationship of AT postoperative values on short and mid-term outcome after cardiac surgery. Between January and June 2005, 405 patients, who underwent cardiac operations at our Institution had AT values available preoperatively and postoperatively. Using Receiver Operating Characteristic curves, a cut-off equal to 63.7% for ICU-arrival AT was chosen in order to divide the entire population in two groups (117 patients with ICU-arrival AT < 63.7%, Low AT group, and 288 patients with ICU-arrival AT > or = 63.7%, High AT group). Objective of the study was to evaluate the predictive role of ICU-arrival AT < 63.7% on in-hospital mortality and morbidity and on 18 months follow-up after cardiac surgery. ICU-arrival AT was significantly lower than preoperative AT (90.7 +/- 16.3% vs. 71.2 +/- 15.1%, P < 0.0001). Patients in the Low AT group were older, more often female, had a worse Euroscore and required longer CPB duration and cross clamp time. They had significantly higher preoperative and postoperative D-dimer levels. ICU arrival AT < 63.7% was not associated wit...Continue Reading
References
Sep 1, 1994·The Annals of Thoracic Surgery·K HashimotoH Kurosawa
May 1, 1993·Chest·J A LorenteA García-Avello
Jun 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·I Pabinger, B Schneider
Jun 3, 1998·Intensive Care Medicine·F BaudoG Calori
Aug 29, 1998·Intensive Care Medicine·B EiseleU Delvos
Aug 6, 1999·Cardiovascular Research·S ZahlerB F Becker
Aug 14, 1999·Critical Care Medicine·M A MartínezJ J Vázquez
Jan 5, 2000·The Annals of Thoracic Surgery·M RossiR Schiavello
Mar 7, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·T F SlaughterC S Greenberg
Oct 26, 2001·JAMA : the Journal of the American Medical Association·B L WarrenUNKNOWN KyberSept Trial Study Group
Feb 6, 2002·The Journal of Thoracic and Cardiovascular Surgery·John H Lemmer, George J Despotis
May 3, 2002·The Journal of Thoracic and Cardiovascular Surgery·Gabriel S AldeaEdward D Verrier
May 23, 2002·Perfusion·Marco RanucciSimonetta Brozzi
Nov 21, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J RoemischC J Wiedermann
Feb 9, 2005·Critical Care Medicine·Marco RanucciSimonetta Brozzi
Jun 23, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Domenico PaparellaEdward Young
Aug 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Alessandro ParolariMarina Camera
Jan 26, 2006·The Journal of Thoracic and Cardiovascular Surgery·Domenico PaparellaStephanie J Brister
Jul 14, 2006·Transfusion·Christine S RinderBrian R Smith
Citations
Jan 19, 2016·Frontiers in Cardiovascular Medicine·Alessandro ParolariElena Tremoli
Feb 11, 2014·The Annals of Thoracic Surgery·Domenico PaparellaTommaso Fiore
Oct 30, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Vicente MuedraBlanca de Prada
Jul 4, 2012·Revista española de anestesiología y reanimación·V Muedra
Dec 18, 2015·Thrombosis and Haemostasis·Jerrold H LevyMarcel Levi
May 29, 2010·British Journal of Haematology·Jecko ThachilVanessa Martlew
Dec 13, 2012·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Tsutomu HattoriMotomi Shiono
Dec 4, 2014·Thrombosis Research·Domingo BarettinoVicente Muedra
Jun 15, 2011·Perfusion·V MuedraJ E Llopis
Apr 1, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Jayanta MukherjiSteven B Edelstein
Mar 16, 2018·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Gülsüm ÖzkanBurhan Turgut
Jan 25, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vicente MuedraLucrecia Moreno
Apr 24, 2018·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Yoshiyuki Nishimura, Yasushi Takagi
Oct 16, 2018·Frontiers in Pharmacology·Vicente MuedraPilar D'Ocón
Dec 26, 2009·Current Opinion in Anaesthesiology