Antithrombin III: Plasma Activity and Reference Range Among Nigerian Blood Donors

The Nigerian Postgraduate Medical Journal
Vincent Oluseye OsunkaluFelix Ngwuli

Abstract

Diagnosis of antithrombin III (ATIII) deficiency as a common cause of thrombophilia is primarily based on the determination of antithrombin levels in plasma using a functional activity assay or an immunological assay, but local reference interval is lacking. The aim of the present study was to determine pattern of antithrombin activity and local reference intervals for ATIII among Nigerians. A cross-sectional study was carried out among healthy blood donors at the Lagos University Teaching Hospital in Nigeria between the age range 18 and 65 years. Structured questionnaires were applied to obtain demographic and clinical history. Percentage ATIII activity was determined using immunoassay technique. Data were analysed using SPSS version 20.0. One hundred and fifty-five healthy blood donors who participated in this study consisted of 84 males and 71 females. The mean age of participants was 35 ± 6.7 years with a modal age range at 25-49 years. The mean percentage ATIII activity was 91.2 ± 14.2% (confidence interval: 69.2-113.2). Reference interval estimated for all the subjects was 62.8-119.6%. ATIII activity was lower in females compared to males (91.1 vs. 94.2; P = 0.03). However, ATIII activity tended to decrease with increasin...Continue Reading

References

Jan 16, 1975·The New England Journal of Medicine·R D Rosenberg
Apr 1, 1994·British Journal of Haematology·G DolanF E Preston
Jul 1, 1993·British Journal of Haematology·R C TaitJ F Davidson
Jul 5, 2005·Blood·David A LaneJames A Huntington
Jan 15, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·M M Patnaik, S Moll
Jun 26, 2009·British Journal of Haematology·Lara N RobertsRoopen Arya
Aug 18, 2009·Transfusion·Nancy M Dunbar, Wayne L Chandler
Jan 23, 2010·American Journal of Clinical Pathology·Gary L Horowitz
Nov 26, 2010·American Journal of Hematology·Bernard Khor, Elizabeth M Van Cott
Apr 5, 2012·American Journal of Hematology·Nicholas V JohnsonElizabeth M Van Cott
Sep 18, 2012·International Journal of Laboratory Hematology·I MackieUNKNOWN British Committee for Standards in Haematology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The Nigerian Postgraduate Medical Journal
O O OladipoO A Afonja
Nigerian Journal of Surgery : Official Publication of the Nigerian Surgical Research Society
Sunday Oladunjoye Ogundele, Stephen Odunayo Ikuerowo
Problemy gematologii i perelivaniia krovi
V K Al'pidovskiĭA A Gerasimov
© 2022 Meta ULC. All rights reserved