Antithrombin III: structural and functional aspects

Biochimie
L MoureyD Moras

Abstract

Antithrombin III is a plasma glycoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 A resolution. The overall topology is similar to that of alpha 1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.

References

Jul 21, 1978·Biochimica Et Biophysica Acta·M W Pomerantz, W G Owen
Oct 15, 1979·FEBS Letters·H JörnvallI Björk
Oct 20, 1975·Biochimica Et Biophysica Acta·W G Owen
Jan 27, 1976·Biochemistry·K KurachiE W Davie
Dec 20, 1989·Journal of Molecular Biology·J P SamamaD Moras
Oct 1, 1989·Baillière's Clinical Haematology·D A Lane, R Caso
Aug 15, 1989·The Biochemical Journal·P E SteinR W Carrell
Feb 15, 1989·The Biochemical Journal·P A PembertonR W Carrell
Apr 1, 1988·The Journal of Clinical Investigation·J Y BorgR W Carrell
May 17, 1988·Biochemistry·P Gettins, B Harten
Jan 1, 1987·Cold Spring Harbor Symposia on Quantitative Biology·R W CarrellD R Boswell
Dec 7, 1973·Nature·P S DamusR D Rosenberg
Jan 1, 1983·Annual Review of Biochemistry·J Travis, G S Salvesen
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T ChandraS L Woo
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T KoideN Sakuragawa
Jan 1, 1983·Haemostasis·J ConardU Abildgaard
Jan 1, 1981·Annals of the New York Academy of Sciences·J ChoayJ Fareed
Jul 31, 1980·Biochemical and Biophysical Research Communications·L T Hunt, M O Dayhoff

❮ Previous
Next ❯

Citations

Jul 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P GettinsM Schapira
Jul 1, 1992·Medicinal Research Reviews·M D Walkinshaw
Apr 1, 1994·Protein Science : a Publication of the Protein Society·R Tyler-CrossR B Harris
Jul 1, 1992·Trends in Cell Biology·P M Hecht, K V Anderson
Aug 28, 2001·Journal of Chromatography. a·R DöngesD Brazel
Sep 27, 2003·Life Sciences·Satomi OnoueKazuhisa Kashimoto
Jun 1, 1996·Blood Reviews·D A LaneS L Thein
Jun 1, 1994·British Journal of Haematology·R J OldsS L Thein
Apr 18, 1994·Annals of the New York Academy of Sciences·P A PatstonM Schapira
Oct 31, 2013·Journal of Cancer Research and Clinical Oncology·Jo-Chi TsengChung-Ching Hua
Mar 28, 2008·Bioorganicheskaia khimiia·I Iu Ponedel'kinaV N Odinokov
Oct 10, 2006·Médecine sciences : M/S·Ludovic Drouet, Laurent Ripoll
Jul 5, 2005·Expert Opinion on Investigational Drugs·W JeskeJ Fareed
Jan 27, 2015·Nature Genetics·Andrew D FooteRichard A Gibbs
May 3, 2002·The Journal of Biological Chemistry·Jerry E ChipukDavid Danielpour
Jan 16, 1992·Nature·J MottonenE J Goldsmith
Feb 25, 2014·Nature Chemical Biology·Yongmei XuJian Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.