Antithrombotic and haemorrhagic effects of synthetic and naturally occurring thrombin inhibitors

Thrombosis Research
B Kaiser, F Markwardt

Abstract

The effects of the synthetic thrombin inhibitor N alpha-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide (beta Nas-Gly-(pAm)Phe-Pip) and the naturally occurring inhibitors hirudin and heparin on the bleeding time were studied in mice and rats by the method of transection of the tail tip and of standardized incision of the tail. With both methods the thrombin inhibitors prolonged the bleeding time in dependence on the dose and the plasma concentration obtained. The transection bleeding time was influenced by the inhibitors in a similar manner, whereas in the case of incision of the tail heparin caused a more pronounced effect than hirudin and beta Nas-Gly-(pAm)Phe-Pip. Comparison of the antithrombotic actions of the inhibitors with their effects on the bleeding time showed that, in contrast to the selective thrombin inhibitors hirudin and beta Nas-Gly-(pAm) Phe-Pip, antithrombotically effective doses of heparin induced a clear prolongation of bleeding time.

References

Apr 1, 1985·Seminars in Thrombosis and Hemostasis·L D Brace, J Fareed
Nov 15, 1985·Thrombosis Research·P Walsmann, F Markwardt
Jan 1, 1980·The Journal of Clinical Investigation·E W SalzmanL Favreau

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Citations

Dec 1, 1988·Trends in Pharmacological Sciences·R B Wallis
Oct 1, 1993·Journal of the American College of Cardiology·E DeutschR W Colman
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S R Hanson, L A Harker
Dec 10, 1991·Clinical Materials·R Vanholder
Jan 3, 1992·The American Journal of Cardiology·R C Becker
Oct 1, 1988·Thrombosis Research·H P KlöckingF Markwardt
Apr 1, 1994·Thrombosis Research·F Markwardt
Jun 1, 1989·Thrombosis Research·F MarkwardtG Nowak
Dec 15, 1992·Thrombosis Research·F MarkwardtM Richter
Dec 1, 1988·Thrombosis Research·F MarkwardtG Vogel

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