Antithrombotic drugs for secondary stroke prophylaxis

Pharmacotherapy
L Creed Pettigrew

Abstract

Stroke is the third most common cause of adult mortality in the United States. Antithrombotic agents form the mainstay of stroke prevention. Aspirin produces a modest reduction in the risk of second stroke and is widely recommended for initial therapy. The thienopyridines ticlopidine and clopidogrel are alternatives for secondary prevention in patients who do not respond to or cannot take aspirin. They are no more effective than aspirin and have been associated with thrombotic thrombocytopenic purpura. The combination of aspirin and extended-release dipyridamole has several mechanisms of action and an additive effect on reducing stroke risk compared with either agent alone. A 2-fold increase in risk reduction and favorable safety profile suggest that the combination can serve as first-line prophylaxis against a second stroke.

References

May 1, 1977·Stroke; a Journal of Cerebral Circulation·W S FieldsR J Hardy
Jul 13, 1978·The New England Journal of Medicine·UNKNOWN Canadian Cooperative Study Group
Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·M L DykenD G Sherman
Dec 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·B FarrellC Warlow
Oct 31, 1991·The New England Journal of Medicine·UNKNOWN Dutch TIA Trial Study GroupAnet van Latum
Aug 1, 1990·Stroke; a Journal of Cerebral Circulation
Feb 8, 1990·The New England Journal of Medicine
Jul 20, 1989·The New England Journal of Medicine·UNKNOWN Steering Committee of the Physicians' Health Study Research Group
Jan 30, 1988·British Medical Journal·R PetoS Norton
Jan 1, 1982·European Journal of Clinical Pharmacology·A DresseG Heinzel
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Dec 1, 1994·Stroke; a Journal of Cerebral Circulation·H Marcussen
Jun 1, 1994·Stroke; a Journal of Cerebral Circulation·J van Gijn, A Algra
Feb 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·A Algra, J van Gijn
Aug 1, 1996·The American Journal of Medicine·A I Schafer
Sep 1, 1996·Stroke; a Journal of Cerebral Circulation·T N TaylorM F Jacobson
Nov 14, 1997·Drugs·A J Coukell, A Markham
Jun 10, 1998·Annals of Internal Medicine·C L BennettD Green
Aug 15, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·B B LoveM Gent
Sep 12, 1998·Annals of Internal Medicine·P J SharisJ Loscalzo
Sep 23, 1998·Neurology·H C Diener
Jun 17, 1999·Archives of Internal Medicine·E S JohnsonL W Dicker
Sep 17, 1999·Archives of Neurology·J L Wilterdink, J D Easton
Dec 14, 1999·British Journal of Clinical Pharmacology·J G TheisS Marshall
Jun 15, 2000·The New England Journal of Medicine·C L BennettH M Tsai

❮ Previous
Next ❯

Citations

Mar 22, 2002·The New England Journal of Medicine·Henry A Waxman
Feb 21, 2009·The New England Journal of Medicine·Seth W GlickmanKevin A Schulman
Jan 25, 2005·The Veterinary Quarterly·S RibbensA de Kruif
Nov 22, 2002·Food Additives and Contaminants·T Berg, D Licht
Jul 26, 2003·Food Additives and Contaminants·P LaierA M Vinggaard
Nov 5, 2003·Food Additives and Contaminants·N H StoffersR Franz
Dec 24, 2005·Critical Reviews in Food Science and Nutrition·Miguel Angel de la Fuente, Manuela Juárez
Nov 9, 2005·Western Journal of Nursing Research·Barbara Wharton McCabeSusan Noble Walker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.