Antithrombotic effect of enoxaparin in clinically healthy cats: a venous stasis model

Journal of Veterinary Internal Medicine
C M Van De WieleK D Sederquist

Abstract

Systemic arterial thromboembolic events are a serious complication of cardiac disease in cats. To determine if enoxaparin induces an antithrombotic effect in cats at a dosage of 1 mg/kg SC q12h and if this antithrombotic effect is predicted by anti-Xa activity. Fourteen clinically healthy cats were divided into 3 groups: control (4 cats), treated and assessed at 4 hours (5 cats), and treated and assessed at 12 hours (5 cats). A venous stasis model was used and the extent of thrombus formation estimated by measuring thrombus weight and accretion of 125I-fibrinogen. Plasma anti-Xa activity was measured in treated cats. There was a significant reduction in thrombus formation in the 4 h group compared with control (median weight, 0.000 versus 0.565mg/mm, P < .01; median % 125I-fibrinogen accretion, 0.0 versus 42.0%, P < .01). There was a reduction in thrombus formation in the 12 h group (median weight, 0.006 mg/mm, P = .09; median % 125I-fibrinogen accretion, 3.83%, P = .09) but this reduction was not significant. The median percent thrombus inhibition for treated cats was 100.0% at 4 hours and 91.4% at 12 hours. Plasma anti-Xa activity was not significantly correlated with thrombus formation. This pilot study demonstrates that eno...Continue Reading

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Citations

Mar 29, 2012·American Journal of Veterinary Research·Nonya N FiakpuiKimberly A Sederquist
Jan 19, 2016·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Daniel F Hogan, Benjamin M Brainard
Oct 4, 2012·Topics in Companion Animal Medicine·Stephanie Ann Smith
Aug 27, 2014·Journal of Veterinary Emergency and Critical Care·Alex M LynchClaire R Sharp
May 9, 2014·The Veterinary Journal·Reinhard MischkeManfred Kietzmann
Oct 8, 2011·The Veterinary Journal·Reinhard MischkeManfred Kietzmann
Sep 7, 2016·Journal of Veterinary Emergency and Critical Care·Amy C Dixon-JimenezGregg S Rapoport
Jun 28, 2012·Journal of Feline Medicine and Surgery·Virginia Luis Fuentes
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Robert GoggsRonald H L Li
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Marie-Claude BlaisClaire R Sharp
Jun 28, 2016·American Journal of Veterinary Research·Jette C Schönig, Reinhard H Mischke
Jun 4, 2016·Journal of the American Animal Hospital Association·Stephanie JohnnidesPaul Eubig
Oct 9, 2021·Journal of Veterinary Pharmacology and Therapeutics·Julianna FrumJohn Thomason
Oct 26, 2021·Journal of Feline Medicine and Surgery·Mark D Kittleson, Etienne Côté

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