PMID: 11345210May 10, 2001Paper

Antithrombotic effects of tetramethylpyrazine in in vivo experiments

International Journal of Hematology
J R SheuM H Yen

Abstract

In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1.5-fold compared with normal saline in severed mesenteric arteries of rats. Continuous infusion of TMPZ (1 microg/g per min) for 10 minutes also significantly increased the bleeding time approximately 1.6-fold, and the bleeding time returned to baseline within 60 minutes after cessation of TMPZ infusion. On the other hand, platelet thrombi formation was induced by irradiation of mesenteric venules with filtered light in mice pre-treated intravenously with fluorescein sodium (10 microg/kg). When it was intravenously injected, TMPZ (250 microg/g) significantly prolonged the latent period of the induction of platelet plug formation in mesenteric venules. TMPZ (250 microg/g) prolonged occlusion time approximately 1.4-fold (183 +/- 18 seconds) compared with that of normal saline (132 +/- 14 seconds). Furthermore, aspirin (300 microg/g) showed similar activity in the prolongation of occlusion time in this experiment. In c...Continue Reading

References

Jan 1, 1990·Seminars in Thrombosis and Hemostasis·R P Rodgers, J Levin
Sep 1, 1985·Journal of Cardiovascular Pharmacology·X Z Dai, R J Bache
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·W K HoC M Lee
Jan 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J R SheuT F Huang
Jan 1, 1964·Scandinavian Journal of Haematology·A NORDOEY, A B CHANDLER

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Citations

Jun 2, 2009·International Journal of Pharmaceutics·Jian FengYouichi Abe
Sep 16, 2008·Bioorganic & Medicinal Chemistry·Yewei SunYuqiang Wang

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