Antithrombotic management and 1-year outcome of patients on oral anticoagulation undergoing coronary stent implantation (from the Registro Regionale Angioplastiche Emilia-Romagna Registry)

The American Journal of Cardiology
A RubboliAntonio Marzocchi

Abstract

Current recommendations for the antithrombotic management of patients receiving oral anticoagulation (OAC) who undergo percutaneous coronary intervention with stent implantation (PCI-S) are based on limited and relatively weak data. To broaden and strengthen available evidence, the management and 1-year outcomes of OAC patients who underwent PCI-S and were included in a prospective, multicenter registry from 2003 to 2007 were evaluated. Among the 632 patients receiving OAC, mostly because of atrial fibrillation (58%), who underwent PCI-S, mostly because of acute coronary syndromes (63%), dual-antiplatelet therapy with aspirin and clopidogrel was the most frequently prescribed at discharge (48%), followed by triple therapy with OAC, aspirin, and clopidogrel (32%) and OAC plus aspirin (18%). The choice of antithrombotic therapy largely matched the thromboembolic risk profiles of patients, with the prescription of regimens including OAC predicted by the presence of non-low-risk features. The cumulative 1-year occurrence of major adverse cardiovascular events was as high as 27% and was not significantly different among the 3 treatment groups. Stroke and stent thrombosis were limited to 2% and 3%, respectively, and although no signi...Continue Reading

References

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Citations

Sep 11, 2014·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Mohan Mallikarjuna Rao EdupugantiAbdul Hakeem
Aug 29, 2014·Journal of Thrombosis and Thrombolysis·Jung Rae Cho, Dominick J Angiolillo
Jul 9, 2016·Journal of Thrombosis and Thrombolysis·Jonathan RilingerChristoph B Olivier
Jun 20, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Ayesha AtherVincent Y See

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