Antithrombotic therapies for elderly patients: handling problems originating from their comorbidities

Clinical Interventions in Aging
Masahisa Arahata, Hidesaku Asakura

Abstract

Compared with younger people, elderly people have higher risks for both thrombosis and bleeding. Furthermore, comorbidities frequently found in elderly patients complicate the management of antithrombotic therapy. Thus, when treating these patients, physicians often find it difficult to incorporate the principles of evidence-based medicine and must determine the best treatment option for each patient. Recently, in the fields of cerebrovascular and cardiovascular diseases, researchers have been rapidly accumulating new data regarding antithrombotic therapy, particularly in the areas of direct oral anticoagulants (DOACs) and dual antiplatelet therapy (DAPT). However, information related to elderly patients receiving antithrombotic therapy is still relatively limited. There are also more and more publications describing how antithrombotic therapy affects the pathogenesis of non-thrombotic diseases. Similarly, the number of reports concerning adherence to this therapy has been increasing lately. However, no review articles detailing these findings have yet been published. In actual clinical practice, antithrombotic therapy in the elderly is not a treatment strategy targeted to only one organ or disease. Rather, it requires an inter...Continue Reading

Citations

May 11, 2021·Seminars in Thrombosis and Hemostasis·Bregje A A HuismanAgnes van der Heide
Jul 18, 2021·BMC Palliative Care·Bregje A A HuismanMonique A H Steegers
Aug 8, 2021·Journal of Clinical Medicine·Ulderico FreoEnzo Nisoli

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