PMID: 7515419Jan 1, 1994Paper

Antithyroid action of ketoconazole: in-vitro studies and rat in-vivo studies

The Journal of Pharmacy and Pharmacology
F CombyC Raby

Abstract

Inspection of the chemical structure of ketoconazole indicates that it may have antithyroid activity. The antithyroid action of this drug was demonstrated in-vitro and in-vivo. In-vitro, it was found to form a complex with iodine (formation constant Kc 141 L mol-1), and to inhibit lactoperoxidase (IC50 2 x 10(-4) M). Its effects in-vivo in the rat were assessed by assay of circulating-thyroxine, and from the histological appearance of the thyroid gland. Thyroid gland weight was increased in rats treated with ketoconazole.

Citations

Feb 6, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·James V HennesseyUNKNOWN American College of Endocrinology (ACE)
Sep 9, 2008·Mayo Clinic Proceedings·Michail S LionakisDimitrios P Kontoyiannis
Jul 17, 1999·Toxicology and Applied Pharmacology·M F SauvageG Lachâtre
Oct 26, 2013·Case Reports in Otolaryngology·Nikhil Dinaker ThadaKishore Chandra Prasad
Aug 24, 1999·The Journal of Pharmacy and Pharmacology·M L BeyssenJ Buxeraud
May 20, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Ruba S DarweeshTamam El-Elimat
Apr 4, 2021·International Journal of Molecular Sciences·Rosa Maria ParagliolaSalvatore Maria Corsello

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