PMID: 9534205Apr 16, 1998Paper

Antithyroid and antiadrenal autoantibodies in antiglomerular basement membrane disease, thin basement membrane disease and Alport syndrome

Pathology
Judy SavigeP Thurlow

Abstract

The basement membranes of the glomerulus, thyroid and adrenal all contain the Goodpasture antigen, the target of autoantibodies in antiglomerular basement membrane (GBM) disease. Antithyroid antibodies can be associated with antiGBM disease, and there have been occasional reports of antithyroid antibodies in Alport syndrome, an inherited kidney disease where the GBM lacks the Goodpasture antigen. The aim of this study was to determine how often antithyroid and antiadrenal autoantibodies occurred in antiGBM disease, Alport syndrome and a related condition, thin basement membrane disease (TBMD). Sera from patients with antiGBM disease (n = 19), Alport syndrome (n = 5) or TBMD (n = 13) were tested for antithyroglobulin, antithyroid microsomal and antiadrenal antibodies. Five of the patients with antiGBM disease (5/19, 26%, P NS) had antimicrosomal, and one had antithyroglobulin, antibodies (1/19, 5%, P NS). No patient with Alport syndrome had antithyroid antibodies. One with TBMD (1/13, 8%, P NS) had antithyroglobulin and antimicrosomal antibodies at titres of 1/400 and 1/25,600, respectively. Both patients with antithyroglobulin antibodies had previously been diagnosed with hypothyroidism. No one with antiGBM disease, Alport synd...Continue Reading

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Citations

Aug 10, 2006·Néphrologie & thérapeutique·Nicolas MaziersYves Pirson
May 10, 2005·Seminars in Nephrology·Martin C Gregory
Jul 10, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M H KownR C Robbins
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Apr 22, 2004·QJM : Monthly Journal of the Association of Physicians·K S EardleyG W Lipkin
Jun 17, 2020·Molecular Genetics & Genomic Medicine·Tomoko HorinouchiKandai Nozu
Jul 4, 2020·Annals of Pediatric Endocrinology & Metabolism·Su-Jeong LeeCheol Woo Ko
Jul 1, 2018·Journal of the American Society of Nephrology : JASN·Tomoko HorinouchiKazumoto Iijima

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