Antithyroid drug-induced agranulocytosis: clinical experience with ten patients treated at one institution and review of the literature

Journal of Endocrinological Investigation
M Meyer-GessnerD Reinwein

Abstract

The frequency, predisposing factors and course of agranulocytosis (granulocytes < 250/microliter) secondary to antithyroid drugs were studied in a cohort of 1256 continuously treated outpatients with hyperthyroidism during the 15 year period from 1973 to 1987. Two cases of agranulocytosis were detected; the frequency was 0.18% (95%-confidence intervals, 0.0-0.44%). This prevalence appears to be lower than reported in previous studies (up to 1.8%). For other adverse drug reactions, there was a clear-cut relationship to initial thionamide dose and to the body mass index; most reactions occurred during the first weeks of treatment. In addition, eight patients referred for thionamide drug- induced agranulocytosis were studied, and the following results obtained: Methimazole dose in patients with agranulocytosis was almost twice as in other patients (63.3 +/- 19.7 vs 34.3 +/- 29.7 mg daily) suggesting that this complication was related to dose. The interval between start of antithyroid drug treatment and first symptoms of agranulocytosis was 33 days (median; range, 23-55 days); hence, prolonged treatment beyond this period would appear relatively safe. Withdrawal of the causative agent and treatment of infection led to recovery of l...Continue Reading

References

Mar 1, 1992·British Journal of Clinical Pharmacology·P C Waller
Apr 1, 1989·The American Journal of the Medical Sciences·M C WernerC S Farah
May 1, 1989·Clinical Endocrinology·H TamaiS Nagataki
Oct 1, 1989·Annals of Internal Medicine·B HeinrichF D Goebel
Jan 1, 1985·Hormone Research·A C Vitug, J M Goldman
Sep 1, 1972·Annals of Internal Medicine·J J Wiberg, F Q Nuttall
Apr 1, 1980·European Journal of Clinical Pharmacology·A MelanderE Wählin-Boll
Dec 1, 1983·The Journal of Clinical Endocrinology and Metabolism·T SankeK Miyamura
Aug 1, 1984·Annals of Internal Medicine·D S CooperE C Ridgeway
Jul 1, 1954·The American Journal of Medicine·T H McGAVACK, J CHEVALLEY
Jun 23, 1956·British Medical Journal·C D BURRELLD DONIACH
Nov 1, 1962·The Journal of New Drugs·W R TROTTER

❮ Previous
Next ❯

Citations

Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·P MezquitaF Escobar-Jimenez
May 13, 1999·Hospital Medicine·A Bhattacharyya, P G Wiles
Sep 27, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P AtkinsB J Phillips
Aug 4, 2006·Therapeutic Drug Monitoring·Shannon M ClarkGary D V Hankins
Aug 19, 2009·Journal of the Chinese Medical Association : JCMA·Ming-Tsung SunKuang-Chung Shih
Feb 3, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Priscilla MutharasanMark Molitch
Mar 27, 2015·Case Reports in Endocrinology·Dimitrios AngelisAlan B Zubrow
May 19, 2009·Thyroid : Official Journal of the American Thyroid Association·Kazuna TakataAkira Miyauchi
Jun 28, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rebecca S BahnUNKNOWN American Association of Clinical Endocrinologists
Jan 21, 2017·Drugs in R&D·Nuno VicenteFrancisco Carrilho
Jun 14, 2020·Journal of Clinical Medicine·Noel Lorenzo-VillalbaEmmanuel Andrès
Feb 11, 1999·Journal of Endocrinological Investigation·P HagagM Weiss
Sep 1, 1995·Clinical Endocrinology·G BenkerD Reinwein
Sep 26, 2008·Thyroid : Official Journal of the American Thyroid Association·Dimitrios ThomasGregory Kaltsas
Feb 1, 1997·Thyroid : Official Journal of the American Thyroid Association·H F Escobar-MorrealeJ M Sancho
Nov 2, 2006·The Annals of Pharmacotherapy·Francisco J VilchezManuel Aguilar-Diosdado
Apr 23, 2011·Thyroid : Official Journal of the American Thyroid Association·Rebecca S Bahn ChairUNKNOWN American Association of Clinical Endocrinologists
Apr 15, 2016·Der Internist·G BeyerA Steveling
Jul 1, 1997·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·S A Westphal
Aug 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossMartin A Walter
Mar 24, 2021·BMJ Case Reports·Richard AmoatengScarlett Austin
Apr 16, 1998·Endocrinology and Metabolism Clinics of North America·D S Cooper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.