PMID: 6989445Feb 1, 1980Paper

Antitreponemal IgE in early syphilis

The British Journal of Venereal Diseases
J D BosR H Cormane

Abstract

Using a solid-phase radioimmunoassay technique, mean serum IgE concentrations were found to be raised in patients with early syphilis. Antitreponemal specificity of the IgE response was investigated by the fluorescent treponemal antibody absorption test using a fluorescein-isothiocyanate-labelled antiserum against the Fc-fragment of human IgE. Validity of this test procedure was assessed by blocking experiments. The results provide evidence of the antitreponemal specificity of the IgE response in syphilis and indicate a possible role for antitreponemal IgE in the pathogenesis of the Jarisch-Herxheimer reaction and in the immune-complex origin of some of the lesions of secondary syphilis.

References

Jan 1, 1977·International Archives of Allergy and Applied Immunology·P J Stallman, R C Aalberse
Jan 1, 1978·Immunological Reviews·O Strannegård, I L Strannegård
Jun 3, 1978·British Medical Journal·G M StirratR J Levinsky
Aug 1, 1976·The British Journal of Venereal Diseases·A E Wilkinson, P Rodin
Aug 1, 1976·The British Journal of Venereal Diseases·R L GreenS J Kraus
Dec 1, 1972·The British Journal of Venereal Diseases·P O'Neill, C S Nicol
Sep 1, 1966·The British Journal of Venereal Diseases·T PutkonenK K Mustakallio

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Citations

Apr 1, 1980·The British Journal of Venereal Diseases·J D BosR H Cormane
Dec 1, 1986·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·J L BenachM G Golightly
Dec 1, 1986·Medical Hypotheses·J J McKennaR Renirie
Apr 1, 1982·International Journal of Dermatology·J D Bos

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