Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids

Journal of Natural Products
Masahiko IsakaRattaket Choeyklin

Abstract

In a continuation of our research into antitubercular lanostane triterpenoids from submerged cultures of Ganoderma species, three strains, Ganoderma orbiforme BCC 22325, Ganoderma sp. BCC 60695, and Ganoderma australe BCC 22314, have been investigated. Fourteen new lanostane triterpenoids, together with 35 known compounds, were isolated. Antitubercular activities of these mycelium-associated Ganoderma lanostanoids against Mycobacterium tuberculosis H37Ra were evaluated. Taken together with the assay data of previously isolated compounds, structure-activity relationships of the antitubercular activity are proposed. Most importantly, 3β- and 15α-acetoxy groups were shown to be critical for antimycobacterial activity. The most potent compound was (24E)-3β,15α-diacetoxylanosta-7,9(11),24-trien-26-oic acid (35).

References

Aug 15, 2006·Phytochemistry·R Russell M Paterson
Mar 29, 2007·Natural Product Reports·Brent R Copp, A Norrie Pearce
Sep 1, 1988·Journal of Natural Products·L J LinS F Yeh
Oct 25, 2012·Journal of Natural Products·José-Luis RíosRosa-María Giner
Jan 3, 2013·Phytochemistry·Masahiko IsakaRattaket Choeyklin
Nov 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qing XiaGaimei She
Mar 22, 2015·Phytochemistry·Karen S BishopLynnette R Ferguson
May 16, 2015·Phytochemistry·Sabulal BabyBalaji Govindan
Dec 31, 2015·Journal of Natural Products·Masahiko IsakaRattaket Choeyklin

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Citations

Nov 10, 2017·Journal of Asian Natural Products Research·Zhen TanJun-Gui Dai
Sep 22, 2017·Natural Product Research·Masahiko IsakaRattaket Choeyklin
Aug 3, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Mohamed F AlajmiJamal M Khaled
May 14, 2021·The Journal of Antibiotics·Panida ChinthanomMasahiko Isaka
Apr 16, 2019·Journal of Natural Products·Masahiko IsakaWilunda Choowong

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