Antitubercular constituents of Valeriana laxiflora

Planta medica
Jian-Qiao GuB N Timmermann

Abstract

Antitubercular bioassay-guided fractionation of the n-hexane- and CH (2)Cl (2)-soluble extracts of the above-ground biomass and roots of Valeriana laxiflora led to the isolation of a new iridolactone, (4R,5R,7S,8S,9S)-7-hydroxy-8-hydroxymethyl-4-methyl-perhydrocyclopenta[ c]pyran-1-one ( 1), and a new lignan, (+)-1-hydroxy-2,6-bis- epi-pinoresinol ( 2), along with eleven known compounds, betulin ( 3), betulinic acid ( 4), 5,7-dihydroxy-3,6,4'-trimethoxyflavone ( 5), 23-hydroxyursolic acid ( 6), oleanolic acid ( 7), tricin ( 8), ursolic acid ( 9), ferulic acid, (+)-1-hydroxypinoresinol, prinsepiol, and 5,7,3'-trihydroxy-4'-methoxyflavone. The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic evidence. The absolute stereochemistry of 1 was determined by chemical transformations and Mosher ester procedures. In a microplate alamar blue assay against Mycobacterium tuberculosis, compounds 2 - 9 exhibited minimum inhibitory concentrations (MIC) of 15.5 - 127 microg/mL, while the other isolates were regarded as inactive (MIC > 128 microg/mL). In addition, all the isolates were tested for cytotoxicity against African green monkey Vero cells in order to evaluate their selectivity potential.

Citations

Nov 29, 2005·Natural Product Reports·Muhammad SaleemYong Sup Lee
Aug 24, 2010·Journal of Medicinal Food·Roberta Gomes CoelhoClaudia Andréa Lima Cardoso
Oct 9, 2013·BMC Complementary and Alternative Medicine·Adelina Jiménez-ArellanesRogelio Hernández-Pando
Sep 23, 2011·Bioinformation·Neeraja DwivediVishwa Mohan Katoch
Jun 30, 2014·BMC Complementary and Alternative Medicine·Rafaele C P AraujoJulio Croda
Aug 3, 2010·Pharmaceutical Biology·Camila B de A CarliIracilda Z Carlos
Mar 1, 2015·Journal of Ethnopharmacology·Haoxin LiChristopher A Gray
Jan 24, 2007·Journal of Ethnopharmacology·Adelina Jiménez-ArellanesJulieta Luna-Herrera
Dec 25, 2008·Phytotherapy Research : PTR·Ming-Fai YeungChun-Tao Che
Jul 25, 2009·Medicinal Research Reviews·Arvind S NegiSuman P S Khanuja
Dec 19, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·C T HiguchiC Q F Leite
Jul 16, 2015·Critical Reviews in Food Science and Nutrition·Jianbo Xiao
Mar 18, 2011·International Journal of Antimicrobial Agents·A MartinsL Amaral
May 27, 2014·Biotechnology Advances·Jianbo XiaoHui Cao
Nov 11, 2016·Natural Product Research·Yue-Ting LiJun Li
Mar 29, 2007·Natural Product Reports·Brent R Copp, A Norrie Pearce
Jan 31, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xinguang SunBaolin Guo
Aug 11, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Laíse Adriane HegetoRosilene Fressatti Cardoso
Oct 17, 2007·Rapid Communications in Mass Spectrometry : RCM·Guoquan YanTiefei Ge
Feb 8, 2019·Journal of Asian Natural Products Research·Fa-Wu DongHong-Ping He
Apr 26, 2006·Phytochemical Analysis : PCA·Jian-Qiao GuBarbara N Timmermann
Jun 12, 2020·Natural Product Research·Nuzhat ShehlaWei Wang
Aug 22, 2020·Future Medicinal Chemistry·Claudia Ta PiresRosilene F Cardoso
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhamad Harith MazlunZunoliza Abdullah
Dec 3, 2020·Natural Product Research·Li-Qiu QuanHong-Mei Li
Jan 1, 2021·Natural Product Research·Cristiane Catela Martins de JesusShaft Corrêa Pinto
Feb 5, 2021·Fitoterapia·Huaran ZhangDongmei Ren
May 1, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Rodolfo B BalbinotDebora C Baldoqui
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shikai SunJing Qu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.