Antituberculosis therapy for 2012 and beyond.

Expert Opinion on Pharmacotherapy
Michael Lauzardo, Charles A Peloquin

Abstract

In terms of human suffering, tuberculosis has a huge impact on global society, making it arguably the most important infectious disease in history. Despite the devastating impact on society, the tools to fight tuberculosis are very limited. Current standard therapy has been used for over 40 years and threats, such as the HIV epidemic and drug-resistant strains, undermine efforts to control the disease. New drugs are needed to address the challenges faced globally. Current therapy is briefly reviewed in this paper and then new doses and combinations of existing drugs are presented. New candidate drugs are also discussed, along with the potential benefits and pitfalls of each of the compounds and approaches to therapy. Despite the need to develop new drugs, the ability of programs to deliver existing therapies must not be neglected. Directly observed therapy and a standard basic level of care for all patients with tuberculosis, regardless of where they reside, is imperative, and will ensure that new drugs and regimens will have the greatest possible impact. New combination regimens, including PA 824 and TMC207, in combination with existing drugs, are very exciting - not only because of their ability to shorten treatment regimens ...Continue Reading

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Citations

Nov 26, 2013·BMC Complementary and Alternative Medicine·Ramón Enrique Robles-ZepedaAdriana Garibay-Escobar
May 23, 2014·Drugs·Abdullah Alsultan, Charles A Peloquin
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Dec 17, 2014·International Journal of Pharmaceutics·Dinh-Duy PhamNicolas Tsapis
Jul 28, 2016·Expert Opinion on Pharmacotherapy·Michael Lauzardo, Charles A Peloquin
Apr 3, 2020·Chemical Biology & Drug Design·Shasank S SwainTahziba Hussain
Aug 14, 2012·Indian Journal of Medical Microbiology·Noton K Dutta, Petros C Karakousis

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