Antituberculous activity of some aryl semicarbazone derivatives

Bioorganic & Medicinal Chemistry Letters
Dharmarajan SriramRathinasabapathy Thirumurugan

Abstract

During the course of our work on the synthesis and screening of new drugs for tuberculosis, we have identified N1-(4-acetamido phenyl)-N4-(2-nitro benzylidene) semicarbazone (1b), which inhibited in vitro Mycobacterium tuberculosis H(37)Rv; 100% inhibition at 1.56 microg/mL. This paper is first of its kind in which aryl semicarbazones are reported to possess antimycobacterials potency greater than p-aminosalicylic acid, ethionamide, ethambutol, ciprofloxacin and kanamycin.

References

Jan 1, 1995·American Journal of Respiratory and Critical Care Medicine·C WhalenJ Ellner
Jul 3, 2003·The Lancet Infectious Diseases·Amy Sarah GinsburgWilliam R Bishai

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Citations

Nov 8, 2011·Acta Crystallographica. Section E, Structure Reports Online·Safa'a Faris KayedIbrahim Baba
Jan 6, 2012·Acta Crystallographica. Section E, Structure Reports Online·Hoong-Kun FunKammasandra N Shivananda
Jan 6, 2012·Acta Crystallographica. Section E, Structure Reports Online·Jirapa HorkaewHoong-Kun Fun
Sep 13, 2012·Acta Crystallographica. Section E, Structure Reports Online·Hoong-Kun FunNishitha A Isloor
Nov 26, 2009·European Journal of Medicinal Chemistry·Fernando R PavanClarice Q F Leite
Jan 29, 2008·Chemical Biology & Drug Design·Márcia da SilvaKátia Cirlene Alves Botelho
Feb 9, 2018·Acta Crystallographica. Section E, Crystallographic Communications·Ming Yueh TanEdward R T Tiekink
Aug 13, 2010·Journal of Inorganic Biochemistry·M Belén TaralloDinorah Gambino

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