Antitumor action of rhodium (I) and iridium (I) complexes

Chemico-biological Interactions
T GiraldiD Stolfa

Abstract

Several rhodium(I) and iridium(I) complexes displayed different degrees of antitumour activity when tested in mice bearing Ehrlich ascites carcinoma. Rhodium (I) and iridium (I) acetylacetonate derivatives caused a high percentage of cures. The rhodium (I) dimers were particularly interesting, since (bis(cycloocta-1,5-diene)micromicron' dichlorodirhodium(I) [RhCODCl]2) was highly effective, whereas its analogues, bis(bicyclo[2,2,1]hepta-2,5-diene)micromicron'-dichlorodirhodium(I) [RhNBDCl]2) and bis(1,5-hexadiene)micromicron' dichlorodirhodium(I) [RhEDCl]2) were virtually inactive. The absence of significant inhibition of DNA, RNA and protein syntheses in tumour cells found for [RhCODCl]2 at therapeutically active dosages, indicates that this substance has a different mechanism of action from that of cis-dichlorodiammine Pt(II) (cis-PDD). The amount of rhodium found in tumour cells after administration of active [RhCODCl]2 was higher than that for [RhEDCl]2, while the rhodium concentration in the ascitic fluid was much higher for [RhEDCl]2. A mechanism based on the chemical properties of the complexes is tentatively proposed for explaining these findings and selective toxicity for tumour cells.

References

Dec 1, 1974·Chemico-biological Interactions·T GiraldiG Mestroni
Apr 26, 1969·Nature·B RosenbergV H Mansour
Feb 1, 1954·The Journal of Experimental Medicine·R DULBECCO, M VOGT

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Citations

Dec 1, 1985·Biological Trace Element Research·D G CraciunescuA Doadrio
Jun 7, 2002·Critical Reviews in Oncology/hematology·N Katsaros, A Anagnostopoulou
Nov 10, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Riccardo PettinariPaul J Dyson
May 16, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Malgorzata BrindellRudi van Eldik
Aug 30, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Isabelle Marie Daubit, Nils Metzler-Nolte
Nov 3, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Sophia HarringerBernhard K Keppler
Mar 30, 2011·Journal of Medicinal Chemistry·Zhe LiuPeter J Sadler
Sep 29, 2017·Inorganic Chemistry·Rajendra Prasad PaitandiDaya Shankar Pandey
Feb 22, 2014·Accounts of Chemical Research·Zhe Liu, Peter J Sadler

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