Abstract
Quercetin is one of the most abundant flavonoids, present in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Green tea is a widely consumed beverage, known for a potential source of free radical scavenging and anti-cancer activities. Herein, we investigate the in vivo antitumor efficacy of quercetin and green tea in human leukemia. Human tumors were xenografted into NOD/SCID mice. Quercetin and green tea reduced tumor growth in HL-60 xenografts accompanied by decreased expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increased expression of BAX, a pro-apoptotic protein. Moreover, caspase-3 was activated to a greater extent after quercetin and green tea treatment. Quercetin and green tea also mediated G1 phase cell cycle arrest in HL-60 xenografts. Treatment with quercetin and green tea induced conversion of LC3-I to LC3-II as well as activation of autophagy proteins, suggesting that quercetin and green tea initiate the autophagic progression. We have provided evidence that quercetin and green tea induces signaling at the level of apoptosis, cell cycle and autophagy which converge to antigrowth effects in HL-60 xenograft mice suggesting that ...Continue Reading
References
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K R Hande
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Anna H WuMalcolm C Pike
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Le JianColin W Binns
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manjeshwar S BaligaSantosh K Katiyar
Apr 6, 2005·Biomedical Research·Masahiko OhataMamoru Isemura
Dec 19, 2006·Cancer Biology & Therapy·Samarn DechsupaSamlee Mankhetkorn
May 19, 2007·Genes & Development·Robin MathewEileen White
Jul 31, 2007·Current Opinion in Immunology·Joseph T Opferman
Dec 25, 2007·Antioxidants & Redox Signaling·Naghma KhanHasan Mukhtar
Jun 28, 2008·Nutrition and Cancer·Suk-Ching LeeYong-Chuan Wong
Jan 27, 2010·Oncogene·S ShimizuY Tsujimoto
Apr 8, 2010·Current Drug Targets·David M LucasA Douglas Kinghorn
Jun 22, 2010·Nature·Christian BehrendsJ Wade Harper
Mar 1, 2012·Cancer Biology & Therapy·Miriam CanaveseNoopur Raje
Sep 6, 2013·Haematologica·Alessio NencioniG Vignir Helgason
Dec 25, 2013·Cell Research·Yoshinori Ohsumi
Oct 9, 2014·Cancer Prevention Research·Victor MasoSara Teresinha Olalla Saad
Oct 22, 2014·Oncology Reports·Lifeng LiuXinhan Zhao
Aug 1, 2015·ACS Applied Materials & Interfaces·Jie DingZhiwei He
Nov 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eileen WhiteChang S Chan
May 21, 2016·Environmental Toxicology·Chien-Han YuanFu-An Chen
Dec 19, 2016·International Journal of Pharmaceutics·Nisha TyagiAmirali Popat
Jan 14, 2017·Pharmacognosy Reviews·Alexander Victor Anand DavidSubramani Parasuraman
Citations
Jun 1, 2018·International Journal of Molecular Sciences·Maiara de Souza OliveiraDaniel Pereira Bezerra
Aug 15, 2018·Medicines·Yasuyoshi MiyataHideki Sakai
Oct 13, 2018·Food & Function·Ran WeiYuefei Wang
Dec 28, 2018·Journal of Cellular Physiology·Adel NaimiSaeed Solali
Oct 1, 2019·Archives of Physiology and Biochemistry·Milad AshrafizadehSaeed Samarghandian
Dec 4, 2019·Nutrition Research Reviews·Sadia AfrinMaurizio Battino
Sep 10, 2020·Environmental Toxicology·Suchismita Daw, Sujata Law
Oct 12, 2018·Cell Death Discovery·Issan ZhangDusica Maysinger
Jul 12, 2020·International Journal of Molecular Sciences·Beatriz Castejón-VegaJosé M Alvarez-Suarez
Mar 1, 2019·Nutrients·Mani Iyer PrasanthTewin Tencomnao
Dec 11, 2019·International Journal of Molecular Sciences·Guo-Yi TangHua-Bin Li
Mar 17, 2020·Cell & Bioscience·Asma VafadarHamed Mirzaei
Sep 16, 2020·International Journal of Molecular Sciences·Monica BenvenutoRoberto Bei
Dec 29, 2020·Frontiers in Pharmacology·Huan ShiJing Zhou
Mar 9, 2021·Leukemia Research·Ammara BatoolHafiz M N Iqbal
Mar 7, 2021·Pharmaceuticals·Paula Garcia-OliveiraMiguel Angel Prieto
Mar 24, 2021·Integrative Cancer Therapies·Andrana K CalgarottoCristiane Okuda Torello
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A AlmatroodiArshad Husain Rahmani
Apr 29, 2021·Scientific Reports·Fernanda Isabel Della ViaCristiane Okuda Torello
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Coralia CotoraciAnca Hermenean
Jun 17, 2021·Journal of Cellular and Molecular Medicine·Wenbing WuJi Liu
Jul 3, 2021·Nutrients·James Michael BrimsonAnchalee Prasansuklab
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhicheng ZhangXin Zhang
Nov 18, 2018·Journal of Ethnopharmacology·Ana Carolina B da C RodriguesDaniel P Bezerra
Dec 1, 2020·ACS Omega·Shao-Qing ChenHong Yuan
Jun 2, 2020·ACS Omega·Bahare SalehiWilliam C Cho