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Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

PloS One

Apr 30, 2009

Regina CencicJerry Pelletier

Abstract

Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to modulate the activity of eIF4A, the DEAD-box RNA helicase subunit of the eukaryotic initiation factor (eI...read more

Mentioned in this Paper

Doxorubicin
Pathologic Cytolysis
Eukaryotic Initiation Factor-4G
Polyribosomes
Benzopyrans
Tumor Cells, Uncertain Whether Benign or Malignant
Prostatic Neoplasms
Biochemical Pathway
Cyclopent
Polyvinylidene fluoride
111
Paper Details
References
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Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

PloS One

Apr 30, 2009

Regina CencicJerry Pelletier

PMID: 19401772

DOI: 10.1371/journal.pone.0005223

Abstract

Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to modulate the activity of eIF4A, the DEAD-box RNA helicase subunit of the eukaryotic initiation factor (eI...read more

Mentioned in this Paper

Doxorubicin
Pathologic Cytolysis
Eukaryotic Initiation Factor-4G
Polyribosomes
Benzopyrans
Tumor Cells, Uncertain Whether Benign or Malignant
Prostatic Neoplasms
Biochemical Pathway
Cyclopent
Polyvinylidene fluoride
111

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Related Papers

Paper Details
References
  • References49
  • Citations89
12345
  • References49
  • Citations89
12345...
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