PMID: 2510169Nov 1, 1989Paper

Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin

Proceedings of the National Academy of Sciences of the United States of America
Janendra K BatraI Pastan

Abstract

LysPE40 is a modified form of Pseudomonas exotoxin that lacks the cell-binding domain and has a chemically reactive lysine residue near the amino terminus. LysPE40 is made in Escherichia coli and secreted into the medium from which it is readily purified. Two immunotoxins were constructed by coupling LysPE40 to an antibody to the human transferrin receptor (TFR) or to an antibody to the human interleukin-2 receptor. These immunotoxins were selectively cytotoxic to receptor-bearing cells in tissue culture. Anti-TFR-LysPE40 given intraperitoneally to mice appeared rapidly in the blood and caused regression of A431 tumors growing as subcutaneous xenografts. These results show that it is possible to cause regression of a solid carcinoma by an immunotoxin if proper targeting can be achieved.

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E Aboud-PirakM Sela
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D J FitzGeraldI Pastan
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M C WillinghamI Pastan
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V K ChaudharyI Pastan
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·V K ChaudharyI Pastan
Nov 20, 1987·Science·E S VitettaJ W Uhr
Dec 5, 1986·Cell·I PastanD J FitzGerald
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T F BumolN O Kaplan

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Citations

Sep 1, 1991·Molecular Immunology·H R HoogenboomJ C Raus
May 27, 1994·Biochimica Et Biophysica Acta·U Brinkmann, I Pastan
Oct 1, 1996·Molecular Medicine Today·U Brinkmann
Jun 6, 2000·Advanced Drug Delivery Reviews·I Pastan, R J Kreitman
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R J KreitmanI Pastan
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U BrinkmannI Pastan
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L H PaiI Pastan
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J K BatraC R King
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·U BrinkmannI Pastan
Jun 23, 1993·Annals of the New York Academy of Sciences·D Fitzgerald, I Pastan
Feb 28, 2014·The Journal of Membrane Biology·Stephanie Tortorella, Tom C Karagiannis
Aug 22, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tracy R DanielsManuel L Penichet
Aug 20, 2011·Biochimica Et Biophysica Acta·Tracy R DanielsManuel L Penichet
Nov 25, 2004·Progress in Biophysics and Molecular Biology·Michael W Parker, Susanne C Feil
Jan 1, 1991·Leukemia Research·A EngertP Thorpe
Feb 26, 2000·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·A E FrankelE A Sausville
Jul 1, 1992·Japanese Journal of Cancer Research : Gann·K OkamotoS Iwasa
Jun 25, 2020·Journal of Mammary Gland Biology and Neoplasia·Xin-Wen KuangChuang Chen
Sep 23, 2020·Biomolecules·Antonella AntignaniDavid J FitzGerald
Jul 10, 2019·Journal of Biological Engineering·Byeong Sung LeeTae Hyeon Yoo
Jan 1, 1990·Annals of the New York Academy of Sciences·P AshornE A Berger
Feb 1, 1995·Journal of Pharmaceutical Sciences·T HoshinoH Toguchi
Nov 22, 1991·Science·I Pastan, D FitzGerald

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