Antitumor activity of a derivative of mitomycin, 7-N-[2-[[2-(gamma-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149), against murine and human tumors and a mitomycin C-resistant tumor in vitro and in vivo

Cancer Chemotherapy and Pharmacology
T TsuruoM Morimoto

Abstract

The antitumor activity of a mitomycin derivative, 7-N-[2[[2-(gamma-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149), was evaluated in murine and human tumor models, including a mitomycin C (MMC)-resistant tumor in vitro and in vivo. KW-2149 showed a profound effect against i.p. inoculated P388 leukemia on both a single and an intermittent administration schedule. Against s.c. implanted colon adenocarcinoma 38 (colon 38). KW-2149 was as effective as MMC in ILS% and in tumor growth inhibition on a single-administration schedule. Both compounds were similarly effective when an intermittent schedule was used. KW-2149 showed activity against human tumor xenografts and was effective in two of four non-small-cell lung carcinomas but was not effective against three gastric adenocarcinomas on the single-administration regimen. The activity of KW-2149 against gastric adenocarcinoma was inferior to that of MMC on a single-administration schedule. However, the antitumor activity of KW-2149 was higher on an intermittent schedule than on a single-administration regimen. The antitumor activity of KW-2149 against human tumor xenografts was similar to that of MMC on an intermittent schedule, and the former drug was effective against both ...Continue Reading

References

Oct 1, 1983·Journal of Medicinal Chemistry·B S IyengarJ E Schurig
Jan 1, 1983·Journal of Medicinal Chemistry·B S IyengarJ E Schurig

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Citations

Jan 1, 1993·Cancer Chemotherapy and Pharmacology·S KobayashiT Hirata
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·R R PerryY Kang
Apr 24, 2009·Archives of Pharmacal Research·Sang Hyup Lee
Feb 3, 2009·Chemical & Pharmaceutical Bulletin·Sang Hyup Lee, Harold Kohn
Jun 11, 2011·Bioorganic & Medicinal Chemistry·Hyun Jung ParkSang Hyup Lee
Sep 11, 2012·Bioorganic & Medicinal Chemistry·Hyoung Rae KimSang Hyup Lee
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melanie B Thomas, James L Abbruzzese
Feb 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeremy KortmanskyGary K Schwartz

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