Antitumor activity of an immunocytokine composed of an anti-GD2 antibody and the IL-15 superagonist RLI.

Oncoimmunology
Marie VincentYannick Jacques

Abstract

The use of interleukin (IL)-15 or the IL-15 superagonist RLI as immunological adjuvants presents many advantages over that of IL-2, including a reduced toxicity and an improved efficacy. We have generated an immunocytokine that specifically targets RLI to a tumor-associated antigen, namely, disialoganglioside GD2. This agent displayed robust antitumor activity in 2 syngeneic murine models of malignant disease.

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Jan 29, 2013·International Journal of Cancer. Journal International Du Cancer·Marie VincentYannick Jacques

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Citations

Apr 9, 2016·Oncoimmunology·Jonathan PolLorenzo Galluzzi
Oct 10, 2015·Oncoimmunology·Fernando ArandaLorenzo Galluzzi
Jul 3, 2015·Oncoimmunology·Jonathan PolLorenzo Galluzzi
Aug 7, 2014·Oncoimmunology·Jonathan PolLorenzo Galluzzi
Sep 10, 2014·Cytokine & Growth Factor Reviews·Geok Choo Sim, Laszlo Radvanyi
Mar 12, 2020·Expert Opinion on Biological Therapy·Karin M KnudsonSofia R Gameiro
Feb 11, 2020·Frontiers in Immunology·Ombretta MelaiuDoriana Fruci
Aug 4, 2016·Immunotherapy·Zulmarie Perez HortaPaul M Sondel
Dec 20, 2017·Experimental Biology and Medicine·Christian FercherRoss T Barnard
Nov 11, 2018·British Journal of Cancer·Pedro BerraondoIgnacio Melero
Feb 26, 2019·Frontiers in Oncology·Gaurav NayyarMitchell S Cairo
Aug 1, 2020·Frontiers in Oncology·Bassel NazhaTaofeek K Owonikoko

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