PMID: 11929303Apr 4, 2002Paper

Antitumor activity of compounds isolated from leaves of Eriobotrya japonica

Journal of Agricultural and Food Chemistry
H ItoTakashi Yoshida

Abstract

In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.

Citations

Nov 8, 2003·Bioorganic & Medicinal Chemistry·Ayako KumagaiShinichi Uesato
Aug 21, 2002·Biological & Pharmaceutical Bulletin·Yutaka NishiokaShojiro Kyotani
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Norihiro BannoHoyoku Nishino
Jun 21, 2011·International Journal of Molecular Sciences·Chunhua ZhouXian Li
Feb 23, 2013·International Journal of Molecular Sciences·Takuhiro UtoYukihiro Shoyama
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Zhijun WangPatrick Chan
Jan 31, 2015·International Journal of Molecular Sciences·Jingxiao ZhangLing Yang
Nov 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Łukasz WoźniakKrystian Marszałek
Jan 26, 2010·Phytochemistry·Zhen ZhangJin-Feng Hu
Apr 27, 2004·Microbiology and Immunology·Keiji FunatogawaYoshikazu Hirai
Oct 4, 2005·Free Radical Biology & Medicine·Katsuhisa SakanoShosuke Kawanishi
May 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hui TanKuniyoshi Shimizu
Aug 15, 2014·Bioscience, Biotechnology, and Biochemistry·Phyu Phyu Khine ZarDe-Xing Hou
Jun 9, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khalid Z MatalkaFadi Qadan
Dec 9, 2016·International Journal of Molecular Sciences·Yilong LiuXian Li
Feb 5, 2014·Bioorganic & Medicinal Chemistry Letters·Taewan KimTae Hoon Kim
Jul 25, 2015·Food & Function·Wenbin YinHaiqing Gao
Jan 9, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenna ZhangKunsong Chen
Dec 5, 2019·Immunological Investigations·Xiaoqing ZhouZhaofeng Huang
Apr 13, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Feng LiYanghao Guo
Jul 28, 2020·Natural Product Research·Abdul RahimAhm Khurshid Alam
Jan 2, 2021·Foods·Janusz MalarzAnna Stojakowska

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