Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models

Future Science OA
María V GiolitoMaría J Rico

Abstract

According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents.

References

Jul 29, 2004·Current Medicinal Chemistry·Duane A Burnett
Oct 22, 2008·Nature Chemical Biology·Andrew L Hopkins
Jun 10, 2009·Journal of the American Chemical Society·Lorenz C Blum, Jean-Louis Reymond
Oct 29, 2010·Methods in Molecular Biology·Roland E Dolle
Nov 18, 2010·Journal of Medicinal Chemistry·Niamh M O'BoyleMary J Meegan
Nov 26, 2010·British Journal of Pharmacology·J P HughesK L Philpott
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Aditya BanerjeeSudhir Kumar
Jul 22, 2014·Angewandte Chemie·K C Nicolaou
Feb 18, 2015·Accounts of Chemical Research·Jean-Louis Reymond
Oct 17, 2017·Anti-cancer Agents in Medicinal Chemistry·Qi GuoMingyu Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
column chromatography
nuclear magnetic resonance
flow cytometry

Software Mentioned

GraphPad
Flowing
Image J
GraphPad Prism

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis