Antitumor activity of Soamsan, a traditional Korean medicine, via suppressing angiogenesis and growth factor transcription

Journal of Ethnopharmacology
Sung Chan YoonKyu Yong Jung

Abstract

Antiangiogenic and antitumor activities of Soamsan known as an anticancer remedy in traditional Korean medicine were examined. In contrast to the normal branching of vascular vessels in chorioallantoic membrane (CAM), blood vessels in CAM treated with Soamsan (50 microg per egg) were run parallel to each other with less branching. Oral administration of Soamsan (20 mg/kg per day) for 4 weeks significantly inhibited the rat corneal neovascularization induced by suture, and the length of blood vessels in Soamsan-treated rat cornea was conspicuously low compared to control. When HT1080 cells, human fibrosarcoma, were treated with 2.18 mg/ml of Soamsan up to 24 h, mRNA transcription of VEGF, TGF-beta and bFGF genes was dramatically reduced in a time-dependent manner. Soamsan showed a prolongation of life span and a reduction of tumor volume in CT-26 cell (colon adenocarcinoma)-bearing mice. These results suggest that antitumor activity of Soamsan may be mediated, at least in part, by antiangiogenic mechanism.

References

Dec 24, 1997·Oncogene·E ShaulianM Oren
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·C K GoldmanD T Curiel
Jul 25, 2000·Journal of Ethnopharmacology·S Kavimani, K T Manisenthlkumar
Apr 12, 2001·Journal of Ethnopharmacology·J K JoseR Kuttan
Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Jan 16, 2002·Current Opinion in Genetics & Development·Lalage M Wakefield, Anita B Roberts
Jul 20, 2002·Journal of Ethnopharmacology·Dong Hoon KwakYoung Kug Choo
Oct 1, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S I JeongK Y Jung

❮ Previous
Next ❯

Citations

Mar 16, 2012·International Journal of Nanomedicine·Zhanrong LiDan Liang
Mar 19, 2011·Science China. Life Sciences·Ji-Young BangIn-Cheol Kang
Aug 25, 2010·Journal of Agricultural and Food Chemistry·Sun Phil ChoiMendel Friedman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.