Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G.

Bioorganic & Medicinal Chemistry Letters
Jonathan W LaneRobert M Williams

Abstract

Analogues of the tetrahydroisoquinoline family of antitumor antibiotics, 3-epi-jorumycin (3) and 3-epi-renieramycin G (4), in addition to their respective parent natural products (-)-jorumycin (1) and (-)-renieramycin G (2) were evaluated against both human colon (HCT-116) and human lung (A549) cancer cell lines. (-)-Jorumycin (1) displayed potent growth inhibition with GI50 values in the low nanomolar range (1.9-24.3 nM), while compounds 2-4 were found to be substantially less cytotoxic (GI50 0.6-14.0 microM).

References

Jul 1, 1991·Journal of Medicinal Chemistry·G C Hill, W A Remers
Jun 9, 2001·Chemico-biological Interactions·M G BirdJ A Bond
May 9, 2002·Chemical Reviews·Jack D Scott, Robert M Williams
Aug 13, 2002·Anti-cancer Drugs·Gregory J AuneYves Pommier
Mar 31, 2005·Journal of the American Chemical Society·Collin ChanSamuel J Danishefsky
Sep 8, 2005·Journal of the American Chemical Society·Jonathan W LaneRobert M Williams

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Citations

Aug 9, 2008·The Journal of Organic Chemistry·Dan Fishlock, Robert M Williams
Sep 28, 2013·Journal of Natural Products·Ruijiao ChenXiaochuan Chen
Feb 6, 2008·Natural Product Reports·John W BluntMichèle R Prinsep
Jul 15, 2011·Acta Crystallographica. Section E, Structure Reports Online·Yanni MaLe Zhou
Nov 18, 2011·Acta Crystallographica. Section E, Structure Reports Online·Yanni MaLe Zhou
Nov 9, 2011·Acta Crystallographica. Section E, Structure Reports Online·Yanni MaLe Zhou
May 12, 2009·Biochemical Pharmacology·Juan F M LealCarlos María Galmarini
Oct 28, 2010·British Journal of Pharmacology·J F M LealC M Galmarini
Mar 28, 2007·Angewandte Chemie·Guillaume Vincent, Robert M Williams
Feb 26, 2009·Natural Product Reports·Carmen Cuevas, Andrés Francesch
Feb 12, 2020·Biomolecules·Edina WangAnabel Sorolla
Dec 17, 2008·Organic & Biomolecular Chemistry·Frank D KingDenis Courtier-Murias
Feb 10, 2009·The Journal of Organic Chemistry·Praew ThansandoteMark Lautens
Sep 19, 2008·Bioorganic & Medicinal Chemistry·Irene OrtínCarmen Avendaño
Oct 31, 2009·Bioorganic & Medicinal Chemistry·Irene OrtínCarmen Avendaño

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