PMID: 2497018Apr 1, 1989Paper

Antitumor activity of the progesterone antagonists ZK 98.299 and RU 38.486 in the hormone-dependent MXT mammary tumor model of the mouse and the DMBA- and the MNU-induced mammary tumor models of the rat

European Journal of Cancer & Clinical Oncology
M R SchneiderM F El Etreby

Abstract

The antitumor activities of the antiprogesterones ZK 98.299 and RU 38.486 (RU 486) were tested in the hormone-dependent MXT(+) mammary tumor model of the mouse and the DMBA- and MNU-induced mammary tumor models of the rat. In the MXT(+)-tumor model, treatment with the two antiprogesterones (1-10 mg/kg daily) starting on day 1 after tumor implantation led to an almost complete inhibition of tumor growth identical to that accomplished with tamoxifen. Treatment of established MXT(+) tumors with ZK 98.299 (1, 10 and 50 mg/mg) resulted in a strong, dose-dependent inhibition of tumor growth. At the 10 and 50 mg doses, the effect of ZK 98.299 was superior to that of tamoxifen (4 mg/kg) and equal to that of ovariectomy and of RU 486, whereas megestrol acetate and medroxyprogesterone acetate had no significant effect. In contrast to the massive induction of cell degeneration and cytolysis in the MXT mammary tumors resulting from ovariectomy, the treatment with the two progesterone antagonists seems rather to trigger differentiation of the mitotically active polygonal tumor cells towards glandular structures and acini with secretory activity as well as towards the development of spindle-shaped necrobiotic cell populations. The weights of...Continue Reading

References

Jan 1, 1988·Journal of Steroid Biochemistry·A E Wakeling, J Bowler
Nov 1, 1986·Journal of Steroid Biochemistry·W ElgerR Rohde
Jan 1, 1986·European Journal of Cancer & Clinical Oncology·A DanguyJ L Pasteels
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·M R Schneider
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Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·M R SchneiderG Ruckdeschel

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Citations

May 1, 1993·Clinical & Experimental Metastasis·Y E ShiE W Thompson
Jan 1, 1994·World Journal of Surgery·K Wong, I C Henderson
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·K Parczyk, M R Schneider
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·M R SchneiderK Pollow
Dec 1, 1990·Breast Cancer Research and Treatment·H MichnaW L McGuire
Nov 1, 1990·Breast Cancer Research and Treatment·E KordonC Dosne Pasqualini
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·M R SchneiderM F el Etreby
Mar 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM F el Etreby
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM R Schneider
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM R Schneider
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·Y NishinoM R Schneider
Apr 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·G VollmerR Knuppen
Mar 1, 1990·Baillière's Clinical Endocrinology and Metabolism·A E Wakeling
Mar 1, 1990·Baillière's Clinical Endocrinology and Metabolism·A HowellH Anderson
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E JacobsJ F Robertson
Apr 24, 1999·The Journal of Steroid Biochemistry and Molecular Biology·M F MontecchiaC Lanari
Jan 8, 1999·Breast Cancer Research and Treatment·M F El EtrebyP V Schoenlein
Aug 8, 1998·Breast Cancer Research and Treatment·M F El Etreby, Y Liang
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J H MartinH W van den Berg
Jun 9, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Tsuyuki NishinoYukishige Nishino
Jun 12, 1995·Annals of the New York Academy of Sciences·H MichnaY Nishino
Jan 1, 1996·Acta Oncologica·K B HorwitzG S Takimoto
Apr 1, 1996·Pharmazie in unserer Zeit·E von Angerer

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