Antitumor Activity of TLR7 Is Potentiated by CD200R Antibody Leading to Changes in the Tumor Microenvironment

Cancer Immunology Research
Zofia PilchT P Rygiel

Abstract

Stimulation of Toll-like receptor 7 (TLR7) activates myeloid cells and boosts the immune response. Previously, we have shown that stimulation of the inhibitory CD200 receptor (CD200R) suppresses TLR7 signaling and that the absence of CD200R signaling leads to a decreased number of papillomas in mice. Here, we investigated the effects of agonistic anti-CD200R on the antitumor activity of a TLR7 agonist (R848) in a syngeneic mouse tumor model. Intratumoral administration of R848 inhibited the growth of the CT26 colon carcinoma and simultaneously decreased CD200R expression in tumor-infiltrating immune cells. The antitumor effects of R848 were potentiated by anti-CD200R. Successfully treated mice were resistant to rechallenge with the same tumor cells. However, the immediate antitumor effects were independent of lymphocytes, because treatment efficacy was similar in wild-type and Rag1tm1Mom mice. Administration of R848, particularly in combination with anti-CD200R, changed the phenotype of intratumoral myeloid cells. The infiltration with immature MHC-II+ macrophages decreased and in parallel monocytes and immature MHC-II- macrophages increased. Combined treatment decreased the expression of the macrophage markers F4/80, CD206, CD...Continue Reading

References

Sep 13, 2006·The British Journal of Dermatology·S F Rajpar, J R Marsden
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Oct 8, 2009·The American Journal of Pathology·Pui Y LeeWestley H Reeves
Dec 3, 2009·Breast Cancer Research and Treatment·Reginald M GorczynskiJulia Behnke
Mar 20, 2010·The Journal of Clinical Investigation·Julien Cherfils-ViciniIsabelle Cremer
Apr 9, 2010·Journal of Innate Immunity·Nathalie KoningJörg Hamann
Sep 22, 2010·Nature Immunology·Subhra K Biswas, Alberto Mantovani
Jan 15, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine ZoglmeierCarole Bourquin
Jan 24, 2012·Current Opinion in Immunology·Tomasz P Rygiel, Linde Meyaard
May 23, 2012·PLoS Pathogens·Guruswamy KarnamLinde Meyaard
Oct 30, 2013·Breast Cancer Research and Treatment·Reginald M GorczynskiKai Yu
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Oct 14, 2014·Frontiers in Immunology·Takumi Kawasaki, Taro Kawai
Jun 21, 2015·Cancer Immunology, Immunotherapy : CII·Erina Koga-YamakawaChiang J Li
Oct 24, 2015·Science·Richard N HannaCatherine C Hedrick
Oct 28, 2016·Scientific Reports·Beichu GuoZihai Li

❮ Previous
Next ❯

Citations

Apr 10, 2020·Scientific Reports·Begum H HoruluogluDennis Klinman
Jul 14, 2020·Frontiers in Oncology·Christiana M NeophytouPanagiotis Papageorgis
Jul 30, 2020·Brain, Behavior, and Immunity·E K GranthamR A Harris
Apr 4, 2021·Cancers·Agata PastorczakMalgorzata Firczuk
May 1, 2021·Cancers·Ewa CendrowiczTomasz P Rygiel
Jun 3, 2021·International Journal of Molecular Sciences·Katarzyna ToneckaTomasz P Rygiel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.