Antitumor activity of water extracts from Cordyceps militaris in NCI-H460 cell xenografted nude mice

Journal of Acupuncture and Meridian Studies
Sang Eun ParkChong-Kwan Cho

Abstract

This experimental study investigated the antitumor effect of Cordyceps militaris in NCI-H406 cell transplanted nude mice. After feeding an aqueous solution of C. militaris extracts in NCI-H460 cell xenografted nude mice for 4 weeks, we measured the size of a tumor mass and calculated the inhibition rate. We also estimated survival time and calculated mean survival time and percent increase in lifespan. Results showed that the inhibition rate of water extract of the 150 mg/kg/day C. militaris-administered group was 94.73-75.08% and that of the 300 mg/kg/day C. militaris-administered group was 85.81-73.81%. The tumor weights and volumes decreased in a dose-dependent manner. Mean survival time of the 150 mg/kg/day C. militaris-administered group was extended to 19.43 +/- 2.44 days and 5.42% increased in lifespan (ILS) and that of the 300 mg/kg/day C. militaris-administered group was 21.86 +/- 3.53 days and 18.61% ILS. The relative liver weight was significantly increased in 300 mg/kg/day C. militaris-administered group, but there was no histopathological difference. In conclusion, C. militaris, shrunk tumors and increased mouse lifespan, suggesting that C. militaris was effective in treating tumors in nude mice.

References

May 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S P LangdonE Boven
Sep 2, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Ulrike LindequistWolf-Dieter Jülich
Jun 22, 2006·Toxicologic Pathology·Albert Y Leung
Nov 13, 2007·International Immunopharmacology·Hwan Mook KimSang-Bae Han
Apr 28, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sang Eun ParkYung Hyun Choi

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Citations

Aug 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana BizarroRaquel T Lima
May 15, 2012·3 Biotech·Seema Patel, Arun Goyal
Apr 28, 2012·British Journal of Pharmacology·Shuhei TakahashiMasanori Kitamura
Jul 25, 2015·The American Journal of Chinese Medicine·Shang-Min ChouTsai-Kun Li
Jul 15, 2015·BMC Complementary and Alternative Medicine·Ru-Ming LiuJian-Hui Xiao
Jul 5, 2015·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Hwan Hee LeeHyosun Cho
Apr 19, 2011·International Immunopharmacology·Jong Seok Lee, Eock Kee Hong
Sep 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Filipa S ReisIsabel C F R Ferreira

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