PMID: 11311065Apr 20, 2001Paper

Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents

Journal of Medicinal Chemistry
D S VanVlietK H Lee

Abstract

2-Fluoropodophyllotoxin (11) and several 4beta-anilino-2-fluoro-4'-O-demethyl analogues were synthesized and evaluated in both antineoplastic and antiviral assays. These compounds were moderately active against some cancer cell lines, but they were less active than the corresponding nonfluorinated analogues. Compound 11 exhibited the best activity against KB carcinoma with a GI(50) of approximately 30 nM. Most compounds exhibited moderate activity against HCMV with ID(50) and ID(90) values in the range of 1 microM and 4 microM, respectively. Both 9 and 11 showed an unusual 10-fold selectivity for HSV-2 compared to HSV-1.

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Citations

Nov 8, 2003·Bioorganic & Medicinal Chemistry·Ahmed KamalSunanda G Dastidar
Feb 26, 2004·Bioorganic & Medicinal Chemistry Letters·J L López-PérezA San Feliciano
Oct 25, 2003·European Journal of Medicinal Chemistry·M Angeles CastroArturo San Feliciano
May 23, 2012·Journal of Medicinal Chemistry·Andrés AbadArturo San Feliciano
May 3, 2011·Journal of Asian Natural Products Research·Yong-En GuoTong-Cun Zhang
Jul 19, 2013·Journal of Asian Natural Products Research·Jing LiuDa-Jiang Huang
May 24, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ajay KumarSanjay V Malhotra
Dec 9, 2004·Chemical Reviews·Jun-An Ma, Dominique Cahard
May 1, 2021·Biomolecules·Zinnia ShahBianca Popovici

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