Antitumor and antioxidant activity of Polyalthia longifolia stem bark ethanol extract

Pharmaceutical Biology
S N ManjulaChamallamudi Mallikarjuna Rao

Abstract

In the present study, the ethanol extract of stem bark of Polyalthia longifolia Benth. and Hook (Annonaceae) was screened for its in vitro and in vivo antitumor activity. In vitro cytotoxicity of P. longifolia extract was assessed in murine cancer cells and in human cancer cells by Trypan blue exclusion assay and MTT assay, respectively. P. longifolia extract showed concentration-dependent cytotoxicity in Ehrlich's ascites carcinoma (EAC) and Dalton's ascites lymphoma (DLA) cells with IC50 values of 45.77 and 52.52 microg/mL, respectively. In the MTT assay, the IC50 values of P. longifolia extract against HeLa and MCF-7 cells were 25.24 and 50.49 microg/mL, respectively. In vivo antitumor activity against Ehrlich's ascites tumor and Dalton's solid tumor models was assessed by administering 50 and 100 mg/kg of P. longifolia extract, i.p., for 7 consecutive days. P. longifolia extract, at a dose of 100 mg/kg, significantly enhanced mean survival time (MST) and marginally improved hematological parameters when compared to EAC control mice. And the same dose significantly reduced the tumor volume as compared to control DLA inoculated mice. Positive control, cisplatin (3.5 mg/kg, i.p., single dose), significantly enhanced MST and im...Continue Reading

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Citations

Dec 3, 2014·Molecular and Cellular Endocrinology·Muheeb BegAnil Nilkanth Gaikwad
Sep 17, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Isha DhamijaK S R Pai
Jun 29, 2012·Chemical Biology & Drug Design·Reshma J NaikPawan G Nayak
Oct 4, 2013·Journal of Oleo Science·Dina Permata SariMamoru Koketsu

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