Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H22 liver tumor-bearing mice

Scientific Reports
Li ChenYing Gao

Abstract

Persimmon (Diospyros kaki L.) leaves are commonly used in Asia as tea infusion and as an agent in traditional medicine. The present study aims to explore the antitumor and immunomodulatory effects of total flavonoids extract from persimmon leaves (PLF) in H22 liver tumor-bearing mice. We found that the PLF showed significant inhibition on the liver tumor growth in mice with a tumor inhibition rate of up to 49.35%. In contrast to the severe side effects of cyclophosphamide (CTX), the PLF exhibited anti-cachexia effect and showed no alternation in the body weight and food intake in mice. Moreover, compared with the vehicle control and CTX group, the PLF significantly enhanced the thymus and spleen indices, level of serum interleukin-18 (IL-18), monocyte/macrophage phagocytosis, level of serum hemolysin, and activity of natural killer (NK) cells. This study demonstrated that the PLF could effectively inhibit liver tumor growth in vivo via enhancement of the immune function in mice, and it displayed the potential to be a safe and effective anticancer agent or functional immune-enhancing agent.

References

Aug 8, 2001·The Journal of Experimental Medicine·S L Swain
Apr 29, 2010·Current Urology Reports·Charles G Drake, Emmanuel S Antonarakis
May 10, 2011·Journal of Mathematical Biology·Urszula LedzewiczHeinz Schättler
Aug 2, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lijun SunYali Zhang
Dec 14, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yang YiZhen-Cheng Wei
Mar 19, 2013·Food Chemistry·Allen Y Chen, Yi Charlie Chen
Oct 29, 2014·World Journal of Hepatology·Mónica Enguita-Germán, Puri Fortes
Dec 30, 2014·World Journal of Hepatology·Shinya HayashiHiroaki Hoshi
Mar 28, 2017·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Aditya Ganeshpurkar, Ajay K Saluja

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Citations

Jan 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young-Ran SongHee-Do Hong
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yongping ZhouXiaoming Ai
Mar 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alena LiskovaPeter Kubatka

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Methods Mentioned

BETA
ELISA

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SPSS

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